Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spect...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-06, Vol.21 (6), p.819
Main Authors: Torres-Mendoza, Daniel, González, Yisett, Gómez-Reyes, José Félix, Guzmán, Héctor M, López-Perez, José Luis, Gerwick, William H, Fernandez, Patricia L, Gutiérrez, Marcelino
Format: Article
Language:English
Subjects:
Animals
Anthozoa - chemistry
anti-inflammatory
cembranolide diterpenes
Diterpenes - administration & dosage
Diterpenes - chemistry
Diterpenes - isolation & purification
Eunicea succinea
Gene Expression Regulation - drug effects
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - genetics
Interleukin-6 - biosynthesis
Interleukin-6 - genetics
Macrophages - drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Panama
Plant Extracts - chemistry
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - genetics
uprolides
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Summary:Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 1-3 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21060819