Fundus Autofluorescence and Optical Coherence Tomography Characteristics in Different Stages of Central Serous Chorioretinopathy

Objective. To describe the morphological changes on fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) imaging at different chronicity of central serous chorioretinopathy (CSC). Methods. This cross-sectional study included patients with CSC of different chronicit...

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Bibliographic Details
Published in:Journal of ophthalmology 2021, Vol.2021, p.6649064-9
Main Authors: Ho, Mary, Kwok, Stephanie H. W., Mak, Andrew C. Y., Lai, Frank H. P., Ng, Danny S. C., Chen, Li Jia, Iu, Lawrence P., Young, Alvin L., Brelen, Marten
Format: Article
Language:English
Subjects:
Comparative analysis
Disease
Ethics
Fluorescence
Investigations
Medical imaging
Medical research
Medicine, Experimental
Photoreceptors
Retina
Retinal detachment
Software
Tomography
Variance analysis
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Summary:Objective. To describe the morphological changes on fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) imaging at different chronicity of central serous chorioretinopathy (CSC). Methods. This cross-sectional study included patients with CSC of different chronicity. Changes in FAF scans and morphological changes on SD-OCT were evaluated and compared at different stages of CSC. Results. Sixty-nine patients were enrolled in the study, with a mean age of 52.1 ± 11.8 years. A distinct hypoautofluorescence (AF) pattern was observed at the leakage point in acute CSC (100%). The leakage site was indistinguishable in 48% of the patients with late-chronic CSC. The majority of acute CSC patients showed hyper-AF in the area of serous retinal detachment (SRD), which persisted in the early-chronic stage of CSC. In late-chronic CSC, many cases of hypo-AF (22.2%) and mixed-pattern AF (14.8%) were observed. SD-OCT revealed evolving features of retinal pigment epithelium (RPE) abnormalities in a time-dependent manner: from peaked PEDs in acute CSC to low-lying PEDs in early-chronic CSC and, eventually, flat, irregular PEDs in late-chronic CSC. The average thickness of the photoreceptor layer (inner and outer segment; IS/OS) was 79 μm in the acute group and 55.2 μm in the chronic group. The photoreceptor layer (IS/OS) height was positively associated with visual acuity (p=0.002). Conclusion. Different stages of CSC present different patterns on FAF and SD-OCT imaging. Chronicity of CSC can be estimated using specific features in these images. Photoreceptor layer (IS/OS) height acts as a good and objective predictor of visual outcomes in CSC patients.
ISSN:2090-004X
2090-0058
DOI:10.1155/2021/6649064