Usefulness of Indian Diabetes Risk Score in Predicting Treatment-Induced Hyperglycemia in Women Undergoing Adjuvant Chemotherapy for Breast Cancer

In the curative treatment of cancer with adjuvant chemotherapy, antineoplastic drugs, along with glucocorticoids, can induce hyperglycemia. The objective of this study was to assess the utility of the Indian Diabetes Risk Score (IDRS) in predicting treatment-induced hyperglycemia in women who were n...

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Bibliographic Details
Published in:South Asian journal of cancer 2023-10
Main Authors: Prasad, Krishna, Hegde, Sanath, Rao, Suresh, D'souza, Rhea Katherine, George, Thomas, Baliga, Manjeshwar Shrinath, Suresh, Sucharitha
Format: Article
Language:English
Subjects:
adjuvant chemotherapy
Breast Cancer
diabetes
hyperglycemia
Indian Diabetes Risk Score
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Summary:In the curative treatment of cancer with adjuvant chemotherapy, antineoplastic drugs, along with glucocorticoids, can induce hyperglycemia. The objective of this study was to assess the utility of the Indian Diabetes Risk Score (IDRS) in predicting treatment-induced hyperglycemia in women who were nondiabetic and normoglycemic at the start of chemotherapy. This prospective study was conducted with nondiabetic women who required adjuvant chemotherapy. Participants voluntarily completed the IDRS, providing information on age, waist circumference, family history of diabetes, and physical activity. Chemotherapy-induced hyperglycemia was defined as fasting blood glucose levels ≥100 mg/dL or random blood glucose levels ≥140 mg/dL during treatment. Data were categorized into women who developed hyperglycemia and those who remained normoglycemic during treatment and were analyzed using Fisher's exact test. A significance level of p 
ISSN:2278-330X
2278-4306
DOI:10.1055/s-0043-1775805