Prevalence of CCR5delta32 in Northeastern Iran

A 32-base pair deletion (∆32) in the open reading frame (ORF) of C-C motif chemokine receptor 5 (CCR5) seems to be a protective variant against immune system diseases, especially human immunodeficiency virus type 1 (HIV-1). We aimed to assess the frequency of CCR5∆32 in the healthy Iranian populatio...

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Bibliographic Details
Published in:BMC medical genetics 2019-11, Vol.20 (1), p.184-184, Article 184
Main Authors: Tajbakhsh, Amir, Fazeli, Mostafa, Rezaee, Mehdi, Ghasemi, Faezeh, Heravi, Mastoureh Momen, Gholoobi, Aida, Meshkat, Zahra
Format: Article
Language:English
Subjects:
Adult
Alleles
CC chemokine receptor type 5 (CCR5)
Cohort Studies
Epidemiology
Europeans
Female
Genetic Predisposition to Disease
Geographic spread
HIV
HIV Infections - genetics
HIV-1
Humans
Immune system
Iran
Male
Middle Aged
Mutation
Rare alleles
Receptors, CCR5 - genetics
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Summary:A 32-base pair deletion (∆32) in the open reading frame (ORF) of C-C motif chemokine receptor 5 (CCR5) seems to be a protective variant against immune system diseases, especially human immunodeficiency virus type 1 (HIV-1). We aimed to assess the frequency of CCR5∆32 in the healthy Iranian population. In this study, 400 normal samples from Khorasan, northeastern Iran, were randomly selected. The frequency of CCR5∆32 carriers was investigated using PCR analysis. Allele prevalence and the fit to the Hardy-Weinberg equilibrium were analyzed. The prevalence of CCR5∆32 in the northeastern population of Iran was 0.016. Four hundred samples were studied, among which one with CCR5 and 11 with CCR5 genotype were detected. This study was the first investigation for an assessment of the prevalence of CCR5∆32 in northeastern Iran. The low prevalence of CCR5∆32 allele in the Iranian population may result in the increased susceptibility to HIV-1. In addition, this prevalence is the same as that of reported in East Asia, while is lower than that in the Europeans.
ISSN:1471-2350
1471-2350
DOI:10.1186/s12881-019-0913-9