Achievement of Low-Density Lipoprotein Cholesterol Targets in CKD

We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. CKD-REIN (NCT03381950), a prospec...

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Bibliographic Details
Published in:Kidney international reports 2019-11, Vol.4 (11), p.1546-1554
Main Authors: Massy, Ziad A., Ferrières, Jean, Bruckert, Eric, Lange, Céline, Liabeuf, Sophie, Velkovski-Rouyer, Maja, Stengel, Bénédicte, Ayav, Carole, Combe, Christian, Fouque, Denis, Frimat, Luc, Herpe, Yves-Edouard, Laville, Maurice, Massy, Ziad, Legrand, Karine, Metzger, Marie, Speyer, Elodie, Moulin, Bruno, Lebrun, Gaétan, Magnant, Éric, Choukroun, Gabriel, Bourdenx, Jean Philippe, Essig, Marie, Azar, Raymond, Smati, Mustafa, Jamali, Mohamed, Klein, Alexandre, Delahousse, Michel, Martin, Séverine, Thervet, Eric, Belenfant, Xavier, Urena, Pablo, Vela, Carlos, Chauveau, Dominique, Panescu, Viktor, Glowacki, François, Hoffmann, Maxime, Hourmant, Maryvonne, Besnier, Dominique, Testa, Angelo, Zaoui, Philippe, Chazot, Charles, Juillard, Laurent, Burtey, Stéphane, Keller, Adrien, Kamar, Nassim
Format: Article
Language:English
Subjects:
cardiovascular disease
chronic kidney diseases
Clinical Research
Life Sciences
lipid-regulating agents
lipids
low-density lipoprotein cholesterol
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Summary:We describe the characteristics of patients with moderate/advanced chronic kidney disease (CKD) according to receipt of lipid-lowering therapy (LLT), and whether they achieved low-density lipoprotein cholesterol (LDL-C) targets for high- and very high-risk patients. CKD-REIN (NCT03381950), a prospective cohort study conducted in 40 nephrology clinics in France, enrolled 3033 patients with moderate (stage G3) or advanced (stage G4/G5) CKD (2013−2016) who had not been on chronic dialysis or undergone kidney transplantation. Data were collected from patients’ interviews and medical records. Patients were followed up at 1 year. Among 2542 patients (mean [SD] age 67 [13] years, 34% women) with LDL-C measurements at baseline (mean [SD] LDL-C 2.7 [1.1] mmol/l; cholesterol 4.8 [1.3] mmol/l), 63% were on LLT; 24% were at high (CKD stage G3, no cardiovascular disease [CVD] or diabetes) and 74% at very high (CKD stage G3 with diabetes or CVD, or CKD stage G4/5) cardiovascular risk. Among high-risk patients, 45% of those on statin and/or ezetimibe achieved the LDL-C treatment target (
ISSN:2468-0249
2468-0249
DOI:10.1016/j.ekir.2019.07.014