Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears

The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals. Thin cardiac strips were isolated from the left ventricles of active and hibernating grizzly bears; and subjected to loaded Mant-ATP chase assays, X-ray diffracti...

Full description

Saved in:
Bibliographic Details
Published in:Molecular metabolism (Germany) 2025-02, Vol.92, p.102084, Article 102084
Main Authors: Van der Pijl, Robbert J., Ma, Weikang, Lewis, Christopher T.A., Haar, Line, Buhl, Amalie, Farman, Gerrie P., Rhodehamel, Marcus, Jani, Vivek P., Nelson, O Lynne, Zhang, Chengxin, Granzier, Henk, Ochala, Julien
Format: Article
Language:English
Subjects:
Heart
Hibernation
Metabolism
Myosin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals. Thin cardiac strips were isolated from the left ventricles of active and hibernating grizzly bears; and subjected to loaded Mant-ATP chase assays, X-ray diffraction and proteomics. Hibernating grizzly bears displayed an unusually high proportion of ATP-conserving super-relaxed cardiac myosin molecules that are likely due to altered levels of phosphorylation and rod region stability. Cardiac myosin depresses the heart's energetic demand during hibernation by modulating its function. •Mammal hibernation subtlety remodels cardiac myosin phosphorylation levels and filament structure.•Mammal hibernation promotes cardiac myosin super-relaxation and energy conservation.•Cardiac myosin contributes to the depressed cardiac metabolic demand during mammal hibernation.
ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2024.102084