The Role of Inflammation and Oxidative Stress in Rheumatic Heart Disease

Rheumatic heart disease (RHD), an acquired valvular disease, remains an important cause of morbidity and mortality in developing countries. This chronic illness starts from untreated streptococcal throat infection, resulting in acute rheumatic fever (ARF) in susceptible individuals. Repeated infecti...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (24), p.15812
Main Authors: Franczyk, Beata, Gluba-Brzózka, Anna, Rysz-Górzyńska, Magdalena, Rysz, Jacek
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Atherosclerosis
Calcification
Cardiac arrhythmia
Cardiovascular disease
Chronic infection
Developing countries
Heart
Heart diseases
Heart valves
Hemodynamics
Humans
Industrialized nations
Infections
Inflammation
Kinases
LDCs
Mineralization
Morbidity
Oxidative Stress
Pathogenesis
Peripheral blood
Pharyngitis
Proteins
Review
Rheumatic diseases
Rheumatic Fever
Rheumatic Heart Disease
valvular disease
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Summary:Rheumatic heart disease (RHD), an acquired valvular disease, remains an important cause of morbidity and mortality in developing countries. This chronic illness starts from untreated streptococcal throat infection, resulting in acute rheumatic fever (ARF) in susceptible individuals. Repeated infections lead to a chronic phase characterized by the damage of heart valves. Inflammation has been found to play important role in the development of this disease. All the studies presented in this review clearly show the involvement of the inflammatory state in the progression of this disease. However, the exact role of cytokines in inflammation sites remains to be examined, since most studies have so far focused on peripheral blood. Such analysis would provide information on inflammatory mechanisms in situ.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232415812