In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility accompanying the development of resistance to...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2012-01, Vol.16 (1), p.78-81
Main Authors: Scheid, Liliane Alves, Nunes Mario, Débora Alves, Kubiça, Thaís Felli, Santurio, Janio Morais, Alves, Sydney Hartz
Format: Article
Language:English
Subjects:
Antifungal agents
Antifungal Agents - pharmacology
Antiparasitic agents
Candida
Candida - classification
Candida - drug effects
Drug resistance, fungal
Drug Resistance, Fungal - drug effects
Drug Synergism
Drug Therapy, Combination
Fluconazole
Fluconazole - pharmacology
Microbial Sensitivity Tests - methods
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Summary:In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility accompanying the development of resistance to fluconazole. Our findings confirmed the ability of C. dubliniensis isolates to become resistant to fluconazole and indicated that this resistance was crossed with ketoconazole, itraconazole, ravuconazole and terbinafine. We also tested combinations of terbinafine, amphotericin B, itraconazole and voriconazole against both groups of isolates in a checkerboard assay. Surprisingly, most combinations evidenced indifferent interactions, and the best synergism appeared when terbinafine and itraconazole were combined against the fluconazole-resistant group.
ISSN:1413-8670
1678-4391
DOI:10.1016/S1413-8670(12)70279-9