Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study

• Published in: Journal of the American Heart Association 2023-09, Vol.12 (17), p.e029399-e029399
• Main Authors: Gao, Jingli, Liu, Yang, Ning, Ning, Wang, Jing, Li, Xiaolan, Wang, Aitian, Chen, Shuohua, Guo, Liang, Wu, Zhaogui, Qin, Xueying, Ma, Yanan, Wu, Shouling
• Format: Article
• Language: English
• Subjects: cardiovascular health; diabetic kidney disease; Life's Essential 8; longitudinal; Original Research; patients with diabetes; trajectory
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.123.029399

Background Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk. Methods and Results A total of 7605 participants, aged 54.32±9.77 years, and 4688 participants, aged 56.11±10.38 years, were included in the longitudinal and trajectory analyses, respectively, from 2006 to 2020. The DKD was confirmed using data collected during each follow‐up. LE8 was based on 4 health behaviors and 4 health factors. The range of each metric was 0 to 100, and the overall LE8 score was calculated as the unweighted average of all 8 component metric scores. The trajectories of LE8 during 2006 to 2010 were classified using latent mixture models. Cox models and restricted cubic splines were applied. After a median follow‐up of 12.41 and 6.71 years in longitudinal and trajectory analyses, respectively, the DKD incidence decreased, with the LE8 level increasing (P‐trend