LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells

Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tu...

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Bibliographic Details
Published in:Tumor biology 2017-10, Vol.39 (10), p.1010428317721440-1010428317721440
Main Authors: Yu, Wanjun, Peng, Weidong, Jiang, Hao, Sha, Hanyun, Li, Jipeng
Format: Article
Language:English
Subjects:
A549 Cells
Aged
Apoptosis
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Cell cycle
Cell growth
Cell Line
Cell Line, Tumor
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Female
Functional analysis
Gastric cancer
Gene Expression Regulation, Neoplastic - genetics
Homeodomain Proteins - genetics
Humans
Laboratories
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Lymph nodes
Lymphatic Metastasis - genetics
Lymphatic Metastasis - pathology
Male
Medical prognosis
Metastases
Metastasis
MicroRNAs
MicroRNAs - genetics
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Non-small cell lung carcinoma
Polymerase chain reaction
Proteins
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
Tissues
Transcription factors
Tumor cell lines
Tumorigenesis
Up-Regulation - genetics
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Summary:Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes non–small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in non–small cell lung cancer tumorigenesis.
ISSN:1010-4283
1423-0380
DOI:10.1177/1010428317721440