Performance evaluation of antigen detection rapid diagnostic test (Ag-RDT) for COVID-19 diagnosis in a primary healthcare center during the Shanghai COVID-19 quarantine period

Rapid and accurate detection of SARS-CoV-2 infection is the cornerstone of prompt patient care. However, the reliability of the antigen rapid diagnostic test (Ag-RDT) in the diagnosis of SARS-CoV-2 infection remains inconclusive. We conducted a field evaluation of Ag-RDT performance during the Shang...

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Bibliographic Details
Published in:Virology journal 2022-09, Vol.19 (1), p.140-6, Article 140
Main Authors: Dong, Lan, Li, Wen-Fang, Jiang, Ying
Format: Article
Language:English
Subjects:
Antigen rapid diagnostic test (Ag-RDT)
Antigens, Viral - analysis
China - epidemiology
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 Testing
Diagnosis
Diagnostic tests
Diagnostic Tests, Routine
Disease prevention
Emergency medical care
Humans
Immune system
Laboratories
N gene
ORF1ab gene
Primary Health Care
Quarantine
Reproducibility of Results
SARS-CoV-2
SARS-CoV-2 - genetics
Sensitivity
Sensitivity and Specificity
Severe acute respiratory syndrome coronavirus 2
Testing
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Summary:Rapid and accurate detection of SARS-CoV-2 infection is the cornerstone of prompt patient care. However, the reliability of the antigen rapid diagnostic test (Ag-RDT) in the diagnosis of SARS-CoV-2 infection remains inconclusive. We conducted a field evaluation of Ag-RDT performance during the Shanghai Coronavirus disease 2019 (COVID-19) quarantine and screened 7225 individuals visiting our Emergency Department. 83 asymptomatic SARS-CoV-2 (+) individuals were enrolled in the current study. Simultaneously, Ag-RDT was performed to evaluate its testing performance. For the Ag-RDT(-) cases, the average cycle threshold (Ct) values of the N gene were 27.26 ± 4.59, which were significantly higher than the Ct value (21.9 ± 4.73) of the Ag-RDT(+) individuals (p 
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-022-01871-6