Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection

People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their CD4+ T cell count after antiretroviral therapy (ART). INRs have low CD4+ T cell counts (

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Bibliographic Details
Published in:The Journal of clinical investigation 2022-05, Vol.132 (9), p.1-11
Main Authors: Ferrari, Brian, Da Silva, Amanda Cabral, Liu, Ken H, Saidakova, Evgeniya V, Korolevskaya, Larisa B, Shmagel, Konstantin V, Shive, Carey, Pacheco Sanchez, Gabriela, Retuerto, Mauricio, Sharma, Ashish Arunkumar, Ghneim, Khader, Noel-Romas, Laura, Rodriguez, Benigno, Ghannoum, Mahmoud A, Hunt, Peter P, Deeks, Steven G, Burgener, Adam D, Jones, Dean P, Dobre, Mirela A, Marconi, Vincent C, Sekaly, Rafick-Pierre, Younes, Souheil-Antoine
Format: Article
Language:English
Subjects:
AIDS/HIV
Antiretroviral therapy
Apoptosis
Bacteria
Bacterial Toxins
Biomedical research
CD4 antigen
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Cell proliferation
Cresol
Drug therapy
Electron microscopy
HIV
HIV Infections
HIV-1
Homeostasis
Human immunodeficiency virus
Humans
Immunological memory
Infections
Infectious disease
Inflammation
Lipids
Lymphocytes
Lymphocytes T
Lymphopenia
Memory cells
Metabolism
Metabolites
Microbiota
Mitochondria
Mortality
p-Cresol
Phenylalanine
Plasma
Proteolysis
rRNA 16S
Solutes
Tyrosine
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Description
Summary:People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their CD4+ T cell count after antiretroviral therapy (ART). INRs have low CD4+ T cell counts (
ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI149571