A Comprehensive Review on the Role of Human Epidermal Growth Factor Receptor 2 (HER2) as a Biomarker in Extra-Mammary and Extra-Gastric Cancers

The human epidermal growth factor receptors (HERs) are expressed abundantly in the human body. The tumorigenic potential of HER2/neu is linked to its overexpression, amplification or somatic mutation. The HER2 gene amplification leading to protein overexpression has been reported in 25–30% of breast...

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Bibliographic Details
Published in:Onco 2023-05, Vol.3 (2), p.96-124
Main Authors: Amisha, Fnu, Malik, Paras, Saluja, Prachi, Gautam, Nitesh, Patel, Tanvi Harishbhai, Roy, Arya Mariam, Singh, Sunny R. K., Malapati, Sindhu Janarthanam
Format: Article
Language:English
Subjects:
biomarker
extra-gastric HER2
extra-mammary HER2
HER2 gene amplification
HER2 overexpression
human epidermal growth factor receptors
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Summary:The human epidermal growth factor receptors (HERs) are expressed abundantly in the human body. The tumorigenic potential of HER2/neu is linked to its overexpression, amplification or somatic mutation. The HER2 gene amplification leading to protein overexpression has been reported in 25–30% of breast cancers and 10–30% of gastric/gastroesophageal cancers. While HER2 is a well-documented predictive, prognostic, and therapeutic marker in breast and gastric/gastroesophageal cancers, its relevance has also been demonstrated in multiple other malignancies. In this article, we will conduct an extensive review of current data pertaining to HER2 amplification, overexpression, or mutation in cancers other than breast and gastric cancers.
ISSN:2673-7523
2673-7523
DOI:10.3390/onco3020008