Bilateral Pleural Mesothelioma In Situ and Peritoneal Mesothelioma In Situ Associated With BAP1 Germline Mutation: A Case Report

Mesothelioma in situ is a recently described precursor to invasive mesothelioma. Thus far, all cases in the literature have involved one pleural cavity or the peritoneal cavity. We describe a patient with biopsy-proven mesothelioma in situ involving both pleural cavities and the peritoneal cavity. G...

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Bibliographic Details
Published in:JTO clinical and research reports 2022-08, Vol.3 (8), p.100356, Article 100356
Main Authors: MacLean, Alyssa, Churg, Andrew, Johnson, Scott Thomas
Format: Article
Language:English
Subjects:
BAP1
Bilateral
Case Report
Mesothelioma in situ
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Summary:Mesothelioma in situ is a recently described precursor to invasive mesothelioma. Thus far, all cases in the literature have involved one pleural cavity or the peritoneal cavity. We describe a patient with biopsy-proven mesothelioma in situ involving both pleural cavities and the peritoneal cavity. Genetic analysis results revealed that the patient had a BAP1 germline mutation. This is the first report of mesothelioma in situ involving multiple body cavities and raises a question of whether such patients will all have BAP1 germline mutations.
ISSN:2666-3643
2666-3643
DOI:10.1016/j.jtocrr.2022.100356