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Antibiotic-Induced Immunosuppression-A Focus on Cellular Immunity
Antibiotics are the fundamental treatment for bacterial infections. However, they are associated with numerous side effects. Their adverse effects on the immune system are increasingly recognised, with several mechanisms identified. In this review, we focus on their direct effects on cellular immuni...
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| Published in: | Antibiotics (Basel) 2024-11, Vol.13 (11), p.1034 |
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| container_issue | 11 |
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| container_title | Antibiotics (Basel) |
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| creator | Snow, Timothy Arthur Chandos Singer, Mervyn Arulkumaran, Nishkantha |
| description | Antibiotics are the fundamental treatment for bacterial infections. However, they are associated with numerous side effects. Their adverse effects on the immune system are increasingly recognised, with several mechanisms identified. In this review, we focus on their direct effects on cellular immunity. We review the effects of antibiotics on mitochondrial function and how they impair specific immune cell functions including chemotaxis, phagocytosis, cytokine production, antigen presentation, and lymphocyte proliferation. Findings are described in a multitude of
and
models. However, their impact on patient immunity and clinical outcomes requires further research. Awareness of the potential adverse effects of antibiotics may improve antimicrobial stewardship. The use of therapeutic drug monitoring may help to reduce dose-dependent effects, which warrants further research. |
| doi_str_mv | 10.3390/antibiotics13111034 |
| format | article |
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and
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and
models. However, their impact on patient immunity and clinical outcomes requires further research. Awareness of the potential adverse effects of antibiotics may improve antimicrobial stewardship. The use of therapeutic drug monitoring may help to reduce dose-dependent effects, which warrants further research.</description><subject>Antibiotics</subject><subject>Antigen presentation</subject><subject>Antigens</subject><subject>antimicrobial</subject><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Care and treatment</subject><subject>Cell-mediated immunity</subject><subject>Cells</subject><subject>Cellular immunity</subject><subject>Chemotaxis</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Complications and side effects</subject><subject>critical illness</subject><subject>Cytokines</subject><subject>Dosage and administration</subject><subject>immune response</subject><subject>Immune system</subject><subject>Immunity (Disease)</subject><subject>Immunosuppression</subject><subject>infection</subject><subject>Infections</subject><subject>lymphocyte</subject><subject>Lymphocytes</subject><subject>Mitochondria</subject><subject>Mitochondrial DNA</subject><subject>monocyte</subject><subject>Neutrophils</subject><subject>Phagocytosis</subject><subject>Pneumonia</subject><subject>Proteins</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Sepsis</subject><subject>Side effects</subject><issn>2079-6382</issn><issn>2079-6382</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptklFrHCEQx6W0NCHNJyiUg770ZVMd3VWfynI07UGgL-2zuOpePXb1qmsh3z5eL73mShRxGP_zk_8wCL0l-IZSiT_qsPjBx8WbTCghBFP2Al0C5rLpqICXT-ILdJ3zDtclCRVYvEYXVLay4yAvUd-fQM0m2GKcXW3muYSYy36fXM4-hqZf3UZT8iqG1dpNU5l0Oqr8cv8GvRr1lN31432Fftx-_r7-2tx9-7JZ93eNYRiWxoyCYGM5xkOLOeCOaccdgIaOsYHVg0EL0Q0GRqDUcQYwWmOpAWh19XeFNkeujXqn9snPOt2rqL36k4hpq3SqNianwAkBsmXWSMp0DS3h1mJmJDjtBFTWpyNrX4bZWePCkvR0Bj1_Cf6n2sbfipBWEgasEj48ElL8VVxe1Oyzqb3RwcWSFSWUspZzLqv0_X_SXSwp1F4dVCBAdJz9U211deDDGOvH5gBVvSAVQ9pWVNXNM6q6rZu9icGNvubPCuixwKSYc3LjySTB6jBJ6plJqlXvnvbnVPN3bugD2dTEwg</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Snow, Timothy Arthur Chandos</creator><creator>Singer, Mervyn</creator><creator>Arulkumaran, Nishkantha</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8395-7857</orcidid><orcidid>https://orcid.org/0000-0001-7942-8007</orcidid><orcidid>https://orcid.org/0000-0002-1042-6350</orcidid></search><sort><creationdate>20241101</creationdate><title>Antibiotic-Induced Immunosuppression-A Focus on Cellular Immunity</title><author>Snow, Timothy Arthur Chandos ; Singer, Mervyn ; Arulkumaran, Nishkantha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-cf810cd700b5072064ae7e22a2644b444b02a886bc2f233e7422fdcd3c225a103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibiotics</topic><topic>Antigen presentation</topic><topic>Antigens</topic><topic>antimicrobial</topic><topic>Bacterial diseases</topic><topic>Bacterial infections</topic><topic>Care and treatment</topic><topic>Cell-mediated immunity</topic><topic>Cells</topic><topic>Cellular immunity</topic><topic>Chemotaxis</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Complications and side effects</topic><topic>critical illness</topic><topic>Cytokines</topic><topic>Dosage and administration</topic><topic>immune response</topic><topic>Immune system</topic><topic>Immunity (Disease)</topic><topic>Immunosuppression</topic><topic>infection</topic><topic>Infections</topic><topic>lymphocyte</topic><topic>Lymphocytes</topic><topic>Mitochondria</topic><topic>Mitochondrial DNA</topic><topic>monocyte</topic><topic>Neutrophils</topic><topic>Phagocytosis</topic><topic>Pneumonia</topic><topic>Proteins</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Sepsis</topic><topic>Side effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snow, Timothy Arthur Chandos</creatorcontrib><creatorcontrib>Singer, Mervyn</creatorcontrib><creatorcontrib>Arulkumaran, Nishkantha</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Biological Sciences</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Antibiotics (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snow, Timothy Arthur Chandos</au><au>Singer, Mervyn</au><au>Arulkumaran, Nishkantha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic-Induced Immunosuppression-A Focus on Cellular Immunity</atitle><jtitle>Antibiotics (Basel)</jtitle><addtitle>Antibiotics (Basel)</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>13</volume><issue>11</issue><spage>1034</spage><pages>1034-</pages><issn>2079-6382</issn><eissn>2079-6382</eissn><abstract>Antibiotics are the fundamental treatment for bacterial infections. 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| subjects | Antibiotics Antigen presentation Antigens antimicrobial Bacterial diseases Bacterial infections Care and treatment Cell-mediated immunity Cells Cellular immunity Chemotaxis Chronic obstructive pulmonary disease Complications and side effects critical illness Cytokines Dosage and administration immune response Immune system Immunity (Disease) Immunosuppression infection Infections lymphocyte Lymphocytes Mitochondria Mitochondrial DNA monocyte Neutrophils Phagocytosis Pneumonia Proteins Review Ribonucleic acid RNA Sepsis Side effects |
| title | Antibiotic-Induced Immunosuppression-A Focus on Cellular Immunity |
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