Biologically Active Compounds in Stizolophus balsamita Inflorescences: Isolation, Phytochemical Characterization and Effects on the Skin Biophysical Parameters

Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-04, Vol.22 (9), p.4428
Main Authors: Nawrot, Joanna, Budzianowski, Jaromir, Nowak, Gerard, Micek, Iwona, Budzianowska, Anna, Gornowicz-Porowska, Justyna
Format: Article
Language:English
Subjects:
Acids
Aging
Antioxidants
Bioactive compounds
Biological activity
Biological effects
Biological properties
Cancer
Cosmetics
Cytotoxicity
Enzymes
Epidermis
Flavonoids
Hydration
natural steroid
Phenolic compounds
Phenols
Phytochemicals
sesquiterpene lactones
Severe acute respiratory syndrome coronavirus 2
simple phenolic compounds
Skin
Steroid hormones
Steroids
Stizolophus balsamita
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Summary:Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and natural steroids have been isolated for the first time in the genus . The MTT assay was employed to study in vitro cytotoxic effects of the taxifolin against human fibroblasts. We also evaluate the possible biological properties/cosmetic effects of extract and taxifolin on the human skin. Sixty healthy Caucasian adult females with no dermatological diseases were investigated. We evaluate the effects of extract and taxifolin on skin hydration and transepidermal water loss (TEWL). It was revealed that extract might decrease TEWL level and fixed the barrier function of the epidermis. The presence of bioactive phytochemical constituents in inflorescences makes them a valuable and safe source for creating new cosmetics and medicines.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22094428