Clinical findings in two cases of atypical scrapie in sheep: a case report

Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features. Most cases are detected in apparently healthy sheep and information on the clinical presentation is limited. This...

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Bibliographic Details
Published in:BMC veterinary research 2007-02, Vol.3 (1), p.2-2, Article 2
Main Authors: Konold, Timm, Davis, Andrew, Bone, Gemma, Bracegirdle, John, Everitt, Sharon, Chaplin, Melanie, Saunders, Ginny C, Cawthraw, Saira, Simmons, Marion M
Format: Article
Language:English
Subjects:
Animals
Brain - pathology
Brain - physiopathology
Case Report
Female
PrPSc Proteins - analysis
PrPSc Proteins - metabolism
Scrapie - diagnosis
Scrapie - metabolism
Scrapie - pathology
Scrapie - physiopathology
Sheep
Trigeminal Nucleus, Spinal - metabolism
Trigeminal Nucleus, Spinal - pathology
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Summary:Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features. Most cases are detected in apparently healthy sheep and information on the clinical presentation is limited. This report describes the clinical findings in two sheep notified as scrapie suspects and confirmed as atypical scrapie cases by immunohistochemistry and Western immunoblotting. Although both sheep displayed signs suggestive of a cerebellar dysfunction there was considerable variation in the individual clinical signs, which were similar to classical scrapie. Any sheep presenting with neurological gait deficits should be assessed more closely for other behavioural, neurological and physical signs associated with scrapie and their presence should lead to the suspicion of scrapie.
ISSN:1746-6148
1746-6148
DOI:10.1186/1746-6148-3-2