Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 immune response by activating ST2− expressed immune cells in various allergic diseases. Howeve...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.6805-12, Article 6805
Main Authors: Mato, Naoko, Hirahara, Kiyoshi, Ichikawa, Tomomi, Kumagai, Jin, Nakayama, Masayuki, Yamasawa, Hideaki, Bando, Masashi, Hagiwara, Koichi, Sugiyama, Yukihiko, Nakayama, Toshinori
Format: Article
Language:English
Subjects:
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692/420/256/2516
Allergic diseases
CD4 antigen
Cell number
Dexamethasone
Epithelial cells
Humanities and Social Sciences
Immune response
Immunological memory
Inflammation
Interleukin 13
Interleukin 5
Leukocytes (eosinophilic)
Lung diseases
Lymphocytes
Lymphocytes T
Memory cells
multidisciplinary
Science
Science (multidisciplinary)
Steroids
Trachea
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Summary:The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 immune response by activating ST2− expressed immune cells in various allergic diseases. However, the involvement of memory-type ST2 + CD4 + T cells in such lung inflammation remains unclear. Here we demonstrated that intratracheal administration of IL-33 resulted in the substantial increase of numbers of tissue-resident memory-type ST2 + CD4 + T cells in the lung. Following enhanced production of IL-5 and IL-13, eosinophilic lung inflammation sequentially developed. IL-33-mediated eosinophilic lung inflammation was not fully developed in T cell-deficient Foxn1 nu mice and NSG mice. Dexamethasone treatment showed limited effects on both the cell number and function of memory-type ST2 + CD4 + T cells. Thus our study provides novel insight into the pathogenesis of eosinophilic lung disease, showing that memory-type ST2 + CD4 + T cells are involved in IL-33-induced eosinophilic inflammation and elicited steroid-resistance.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-06962-x