High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries

The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The described methodology is not intended to yield quantitat...

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Bibliographic Details
Published in:SLAS discovery 2024-04, Vol.29 (3), p.100149-100149, Article 100149
Main Authors: Brea, Jose, Varela, Maria J., Daudey, Geert A., Loza, Maria I.
Format: Article
Language:English
Subjects:
High-Throughput Screening Assays - methods
Nephelometry and Turbidimetry - methods
Small Molecule Libraries - chemistry
Solubility
Water - chemistry
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Summary:The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The described methodology is not intended to yield quantitative solubility values of the studied compounds but can be used as a primary solubility assessment of large chemical libraries, to guide hit prioritization after High Throughput Screening (HTS) campaigns.
ISSN:2472-5552
2472-5560
DOI:10.1016/j.slasd.2024.100149