High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries

The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The described methodology is not intended to yield quantitat...

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Published in:SLAS discovery 2024-04, Vol.29 (3), p.100149-100149, Article 100149
Main Authors: Brea, Jose, Varela, Maria J., Daudey, Geert A., Loza, Maria I.
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description The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The described methodology is not intended to yield quantitative solubility values of the studied compounds but can be used as a primary solubility assessment of large chemical libraries, to guide hit prioritization after High Throughput Screening (HTS) campaigns.
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title High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries
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