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Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features
Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-asso...
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| Published in: | Mediators of inflammation 2016-01, Vol.2016 (2016), p.1-10 |
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| creator | Chen, Guan-Ying Lu, Rui Du, Ge-Fei Zhang, Jing Tan, Ya-Qin Zhou, Gang |
| description | Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed that IGF1 expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition, ATG9B mRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression of HGS, ESR1, and SNCA between OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns. |
| doi_str_mv | 10.1155/2016/4867368 |
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Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed that IGF1 expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition, ATG9B mRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression of HGS, ESR1, and SNCA between OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.</description><identifier>ISSN: 0962-9351</identifier><identifier>EISSN: 1466-1861</identifier><identifier>DOI: 10.1155/2016/4867368</identifier><identifier>PMID: 26980945</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Age ; alpha-Synuclein - metabolism ; Antigen presentation ; Apoptosis ; Autophagy ; Cytotoxicity ; Disease ; Endosomal Sorting Complexes Required for Transport - metabolism ; Estrogen Receptor alpha - metabolism ; Female ; Gene expression ; Gene Expression Regulation - genetics ; Gene Expression Regulation - physiology ; Genes ; Homeostasis ; Hospitals ; Humans ; Laboratories ; Lichen planus ; Lichen Planus, Oral - genetics ; Lichen Planus, Oral - metabolism ; Lichen Planus, Oral - pathology ; Lymphocytes ; Male ; Middle Aged ; Phosphoproteins - metabolism ; RNA ; Studies ; T cell receptors ; T cells ; T-Lymphocytes - metabolism ; Tumor necrosis factor-TNF ; Young Adult</subject><ispartof>Mediators of inflammation, 2016-01, Vol.2016 (2016), p.1-10</ispartof><rights>Copyright © 2016 Ya-Qin Tan et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Ya-Qin Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Ya-Qin Tan et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-b288d1a0cfd318a6258f970e2cfb951341414ebb6b1e29c1d06eac5cbed048673</citedby><cites>FETCH-LOGICAL-c604t-b288d1a0cfd318a6258f970e2cfb951341414ebb6b1e29c1d06eac5cbed048673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1768534179/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1768534179?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26980945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Giovarelli, Mirella</contributor><creatorcontrib>Chen, Guan-Ying</creatorcontrib><creatorcontrib>Lu, Rui</creatorcontrib><creatorcontrib>Du, Ge-Fei</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Tan, Ya-Qin</creatorcontrib><creatorcontrib>Zhou, Gang</creatorcontrib><title>Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features</title><title>Mediators of inflammation</title><addtitle>Mediators Inflamm</addtitle><description>Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed that IGF1 expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition, ATG9B mRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression of HGS, ESR1, and SNCA between OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.</description><subject>Adult</subject><subject>Age</subject><subject>alpha-Synuclein - metabolism</subject><subject>Antigen presentation</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Cytotoxicity</subject><subject>Disease</subject><subject>Endosomal Sorting Complexes Required for Transport - metabolism</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - genetics</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genes</subject><subject>Homeostasis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lichen planus</subject><subject>Lichen Planus, Oral - genetics</subject><subject>Lichen Planus, Oral - metabolism</subject><subject>Lichen Planus, Oral - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Mediators of inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Guan-Ying</au><au>Lu, Rui</au><au>Du, Ge-Fei</au><au>Zhang, Jing</au><au>Tan, Ya-Qin</au><au>Zhou, Gang</au><au>Giovarelli, Mirella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features</atitle><jtitle>Mediators of inflammation</jtitle><addtitle>Mediators Inflamm</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0962-9351</issn><eissn>1466-1861</eissn><abstract>Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease. Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity. The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP. Five differentially expressed autophagy-associated genes were identified by autophagy array. Quantitative real-time RT-PCR results confirmed that IGF1 expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients. In addition, ATG9B mRNA levels were significantly lower in nonerosive OLP patients. However, no significant differences were found in the expression of HGS, ESR1, and SNCA between OLP patients and controls. Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26980945</pmid><doi>10.1155/2016/4867368</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age alpha-Synuclein - metabolism Antigen presentation Apoptosis Autophagy Cytotoxicity Disease Endosomal Sorting Complexes Required for Transport - metabolism Estrogen Receptor alpha - metabolism Female Gene expression Gene Expression Regulation - genetics Gene Expression Regulation - physiology Genes Homeostasis Hospitals Humans Laboratories Lichen planus Lichen Planus, Oral - genetics Lichen Planus, Oral - metabolism Lichen Planus, Oral - pathology Lymphocytes Male Middle Aged Phosphoproteins - metabolism RNA Studies T cell receptors T cells T-Lymphocytes - metabolism Tumor necrosis factor-TNF Young Adult |
| title | Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features |
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