Antibacterial effect of a gingival patch containing nano-emulsion of red dragon fruit peel extract on Porphyromonas gingivalis , Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum assessed in vitro

The most common bacteria causing periodontitis were and . At present, plants are considered a valuable source of natural materials for use in the development of antimicrobial, anti-inflammatory and antioxidant agents. or red dragon fruit peel extract (RDFPE) contains terpenoids, and flavonoids can b...

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Published in:Journal of oral biology and craniofacial research (Amsterdam) 2023-05, Vol.13 (3), p.386-391
Main Authors: Diyatri, Indeswati, Juliastuti, Wisnu Setyari, Ridwan, Rini Devijanti, Ananda, Ghinalya Chalbi, Waskita, Fuad Adhi, Juliana, Nita Vania, Khansa, Shafa Putri, Pratiwi, Reinaya Tifa, Putri, Cindy Ramadhan
Format: Article
Language:English
Subjects:
Antibacterial
Gingival patch
Nano-emulsion
Periodontitis
Red dragon fruit
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Summary:The most common bacteria causing periodontitis were and . At present, plants are considered a valuable source of natural materials for use in the development of antimicrobial, anti-inflammatory and antioxidant agents. or red dragon fruit peel extract (RDFPE) contains terpenoids, and flavonoids can be an alternative. The gingival patch (GP) has been designed to ensure drug delivery and absorption into tissue targets. To assess the effect of a mucoadhesive gingival patch containing nano-emulsion of red dragon fruit peel extract (GP-nRDFPE) in inhibiting and as compared to control groups. Inhibition by diffusion method was carried out in and medium. The test material was gingival patch mucoadhesive containing nano-emulsion red dragon fruit peel extract (GP-nRDFPR), gingival patch mucoadhesive containing red dragon fruit peel extract (GP-RDFPE), gingival patch mucoadhesive containing doxycycline (GP-dcx) and blank gingival patch (GP), conducted in four replications. The differences in the inhibition were analyzed using ANOVA and post hoc tests (p 
ISSN:2212-4268
DOI:10.1016/j.jobcr.2023.03.011