Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts

Pheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (UV) B-stimulated CCD-986sk fibroblasts. PA, P...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2021-02, Vol.11 (2), p.147
Main Authors: Lee, Hwa, Park, Ho-Yong, Jeong, Tae-Sook
Format: Article
Language:English
Subjects:
Aging
Aging (artificial)
Aging (natural)
Algae
antiwrinkle
c-Jun protein
Cancer
Cell growth
Chlorophyll
Collagen
Collagen (type I)
Cosmetics
Derivatives
Fibroblasts
Gelatinase A
Gelatinase B
Gene expression
Hepatitis
Interstitial collagenase
JNK protein
Kinases
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
Natural resources
NF-κB protein
pheophorbide a derivatives
Phosphorylation
Procollagen
Protein kinase
Reactive oxygen species
Senescence
Skin
Transcription factors
Ultraviolet radiation
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Summary:Pheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (UV) B-stimulated CCD-986sk fibroblasts. PA, PyroPA, and PyroPA-ME effectively suppressed reactive oxygen species accumulation in UVB-exposed CCD-986sk fibroblasts. All three pheophorbides also reduced UVB-induced matrix metalloproteinase (MMP)-1 secretion and mRNA expression of , , and . Treatment with pheophorbides resulted in increased procollagen synthesis, and this required enhancement of procollagen type I C-peptide content and mRNA expression of collagen type I alpha 1 ( ) and in CCD-986sk cells. These antiwrinkle effects were more potent with PA and PyroPA than with PyroPA-ME. Furthermore, PA and PyroPA suppressed UVB-induced phosphorylation of extracellular signal-regulated protein kinase and c-Jun N-terminal kinase but not p38. Moreover, all three pheophorbides inhibited NF-κB p65 phosphorylation. Therefore, these pheophorbides, especially PA and PyroPA, can be used as antiwrinkle agents, and PA- or PyroPA-rich natural resources can be used in functional cosmetics.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11020147