Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class of therapeutics may change the field of disease treatment and personalized medicine since it can cure diseases. However, drug delivery systems are crucial for these therapeutics...

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Bibliographic Details
Published in:OpenNano 2023-05, Vol.11, p.100132, Article 100132
Main Authors: Nsairat, Hamdi, Alshaer, Walhan, Odeh, Fadwa, Esawi, Ezzaldeen, Khater, Dima, Bawab, Abeer Al, El-Tanani, Mohamed, Awidi, Abdalla, Mubarak, Mohammad S.
Format: Article
Language:English
Subjects:
ASO
CRISPR/Case9
Drug delivery
Liposomes
miRNA
mRNA
Nucleic acid therapeutics
Plasmid
shRNA
siRNA
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Summary:Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class of therapeutics may change the field of disease treatment and personalized medicine since it can cure diseases. However, drug delivery systems are crucial for these therapeutics to fulfill their potential. Liposomes have long been considered ideal platforms for systemic drugs delivery. Considering the development in cancer therapeutics, this work emphases on the current advancements in liposomes’ Nano-formulations, functionalization, and design and how it has been applied to nucleic acid therapeutics. Accordingly, this review covers the literature that deals with liposomes in nucleic acid therapy.
ISSN:2352-9520
2352-9520
DOI:10.1016/j.onano.2023.100132