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Low-intensity continuous ultrasound to inhibit cancer cell migration

In recent years, it has been verified that collective cell migration is a fundamental step in tumor spreading and metastatic processes. In this paper, we demonstrate for the first time how low-intensity ultrasound produces long-term inhibition of collective migration of epithelial cancer cells in wo...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2023-01, Vol.10, p.842965-842965
Main Authors: González, Itziar, Luzuriaga, Jon, Valdivieso, Alba, Candil, Manuel, Frutos, Jesús, López, Jaime, Hernández, Luis, Rodríguez-Lorenzo, Luis, Yagüe, Virginia, Blanco, Jose Luis, Pinto, Alberto, Earl, Julie
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Language:English
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Summary:In recent years, it has been verified that collective cell migration is a fundamental step in tumor spreading and metastatic processes. In this paper, we demonstrate for the first time how low-intensity ultrasound produces long-term inhibition of collective migration of epithelial cancer cells in wound healing processes. In particular, we show how pancreatic tumor cells, PANC-1, grown as monolayers respond to these waves at frequencies close to 1 MHz and low intensities (
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.842965