First Self-Assembly of Dihydroxy Triterpenoid Maslinic Acid Yielding Vesicles

Maslinic acid, a naturally occurring dihydroxy triterpenoid having a 6-6-6-6-6 fused pentacyclic structure, is extractable from the fruits of olive (Olea europaea). As part of our ongoing investigations on the self-assembly of natural products, herein, we report the results of our detailed investiga...

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Bibliographic Details
Published in:ACS omega 2019-04, Vol.4 (4), p.7684-7690
Main Authors: Bag, Braja Gopal, Hasan, Sk Nurul, Ghorai, Subrata, Panja, Saikat Kumar
Format: Article
Language:English
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Summary:Maslinic acid, a naturally occurring dihydroxy triterpenoid having a 6-6-6-6-6 fused pentacyclic structure, is extractable from the fruits of olive (Olea europaea). As part of our ongoing investigations on the self-assembly of natural products, herein, we report the results of our detailed investigation on the self-assembly of maslinic acid in different liquids. The triterpenoid self-assembled in aqueous binary liquid mixtures yielding vesicles of nano to micrometer diameters. Detailed characterization of the self-assemblies was carried out by scanning electron microscopy, high-resolution transmission electron microscopy, atomic force microscopy, optical microscopy, Fourier-transform infrared spectroscopy, and low-angle X-ray diffraction studies. The vesicular self-assemblies were capable of entrapping fluorophores including the chemotherapeutic anticancer drug doxorubicin. Triton X-100-triggered release of the encapsulated drug was also demonstrated via rupture of vesicles.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.8b03667