Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is...

Full description

Saved in:
Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2018-01, Vol.54 (3)
Main Authors: Ciftci, Osman, Duman, Ahmet Sefa, Turkmen, Neşe Basak, Taslıdere, Aslı
Format: Article
Language:English
Subjects:
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Antioxidants
Beta-glucan/protective effects
Cardiotoxicity
Enzymes
Heart
Laboratory animals
Lipid peroxidation
Lipids
Oxidative stress
PHARMACOLOGY & PHARMACY
Proteins
Rats
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763
cites cdi_FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763
container_end_page
container_issue 3
container_start_page
container_title Brazilian Journal of Pharmaceutical Sciences
container_volume 54
creator Ciftci, Osman
Duman, Ahmet Sefa
Turkmen, Neşe Basak
Taslıdere, Aslı
description 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.
doi_str_mv 10.1590/s2175-97902018000317674
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_2f0a7669f02a462aa2f42d5c2542f2df</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S1984_82502018000300623</scielo_id><doaj_id>oai_doaj_org_article_2f0a7669f02a462aa2f42d5c2542f2df</doaj_id><sourcerecordid>2484238623</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763</originalsourceid><addsrcrecordid>eNplkUtvEzEUhUcIJKrS34ClbjPF78eypBQqVWJBWVs3fiSOJuNgOxUs-O-dZFBAYnV9fc93dKTTde8JviHC4A-VEiV6owymmGiMMSNKKv6quzgfXv_zfttd1bqdZERwbbi46H5_DA369XBwMKJ9Cc9hbBW1_DM5FGIMbtpyRHTBFmqh-6fl3R1KI2qh7E6HSeihpeeAYPRok2rLe2ibPOR1cjAgDztYhyOyCVAaaqnWQziSBVp9172JMNRw9Wdedt_vPz0tv_SPXz8_LG8fe8eZab2BuDIiMk2U5hFWVMbgGRVMeSO4W3lphGdOakk8FUorLowmXgtKiHdKssvuYfb1GbZ2X9IOyi-bIdnTRy5rO4VLbgiWRgxKShMxBS4pAI2ceuGo4DRSHyevm9mruhSGbLf5UMYpvP1GjOZWU3HuAmNJ2QRcz8C-5B-HUNtfhHLNKdOzSs0qV3KtJcRzTILtsWt76tr-1zV7AZZRmCY</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2484238623</pqid></control><display><type>article</type><title>Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats</title><source>Publicly Available Content (ProQuest)</source><source>SciELO</source><creator>Ciftci, Osman ; Duman, Ahmet Sefa ; Turkmen, Neşe Basak ; Taslıdere, Aslı</creator><creatorcontrib>Ciftci, Osman ; Duman, Ahmet Sefa ; Turkmen, Neşe Basak ; Taslıdere, Aslı</creatorcontrib><description>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.</description><identifier>ISSN: 2175-9790</identifier><identifier>ISSN: 1984-8250</identifier><identifier>EISSN: 2175-9790</identifier><identifier>DOI: 10.1590/s2175-97902018000317674</identifier><language>eng</language><publisher>Sao Paulo: Universidade de Sao Paulo Faculdade de Ciencias</publisher><subject>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) ; Antioxidants ; Beta-glucan/protective effects ; Cardiotoxicity ; Enzymes ; Heart ; Laboratory animals ; Lipid peroxidation ; Lipids ; Oxidative stress ; PHARMACOLOGY &amp; PHARMACY ; Proteins ; Rats ; Statistical analysis</subject><ispartof>Brazilian Journal of Pharmaceutical Sciences, 2018-01, Vol.54 (3)</ispartof><rights>2018. This work is published under https://creativecommons.org/licenses/by/4.0/deed.en (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763</citedby><cites>FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2484238623/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2484238623?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,24150,25753,27924,27925,37012,44590,75126</link.rule.ids></links><search><creatorcontrib>Ciftci, Osman</creatorcontrib><creatorcontrib>Duman, Ahmet Sefa</creatorcontrib><creatorcontrib>Turkmen, Neşe Basak</creatorcontrib><creatorcontrib>Taslıdere, Aslı</creatorcontrib><title>Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats</title><title>Brazilian Journal of Pharmaceutical Sciences</title><addtitle>Braz. J. Pharm. Sci</addtitle><description>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.</description><subject>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)</subject><subject>Antioxidants</subject><subject>Beta-glucan/protective effects</subject><subject>Cardiotoxicity</subject><subject>Enzymes</subject><subject>Heart</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Oxidative stress</subject><subject>PHARMACOLOGY &amp; PHARMACY</subject><subject>Proteins</subject><subject>Rats</subject><subject>Statistical analysis</subject><issn>2175-9790</issn><issn>1984-8250</issn><issn>2175-9790</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNplkUtvEzEUhUcIJKrS34ClbjPF78eypBQqVWJBWVs3fiSOJuNgOxUs-O-dZFBAYnV9fc93dKTTde8JviHC4A-VEiV6owymmGiMMSNKKv6quzgfXv_zfttd1bqdZERwbbi46H5_DA369XBwMKJ9Cc9hbBW1_DM5FGIMbtpyRHTBFmqh-6fl3R1KI2qh7E6HSeihpeeAYPRok2rLe2ibPOR1cjAgDztYhyOyCVAaaqnWQziSBVp9172JMNRw9Wdedt_vPz0tv_SPXz8_LG8fe8eZab2BuDIiMk2U5hFWVMbgGRVMeSO4W3lphGdOakk8FUorLowmXgtKiHdKssvuYfb1GbZ2X9IOyi-bIdnTRy5rO4VLbgiWRgxKShMxBS4pAI2ceuGo4DRSHyevm9mruhSGbLf5UMYpvP1GjOZWU3HuAmNJ2QRcz8C-5B-HUNtfhHLNKdOzSs0qV3KtJcRzTILtsWt76tr-1zV7AZZRmCY</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Ciftci, Osman</creator><creator>Duman, Ahmet Sefa</creator><creator>Turkmen, Neşe Basak</creator><creator>Taslıdere, Aslı</creator><general>Universidade de Sao Paulo Faculdade de Ciencias</general><general>Universidade de São Paulo, Faculdade de Ciências Farmacêuticas</general><general>Universidade de São Paulo</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>20180101</creationdate><title>Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats</title><author>Ciftci, Osman ; Duman, Ahmet Sefa ; Turkmen, Neşe Basak ; Taslıdere, Aslı</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)</topic><topic>Antioxidants</topic><topic>Beta-glucan/protective effects</topic><topic>Cardiotoxicity</topic><topic>Enzymes</topic><topic>Heart</topic><topic>Laboratory animals</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Oxidative stress</topic><topic>PHARMACOLOGY &amp; PHARMACY</topic><topic>Proteins</topic><topic>Rats</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciftci, Osman</creatorcontrib><creatorcontrib>Duman, Ahmet Sefa</creatorcontrib><creatorcontrib>Turkmen, Neşe Basak</creatorcontrib><creatorcontrib>Taslıdere, Aslı</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SciELO</collection><collection>Directory of Open Access Journals</collection><jtitle>Brazilian Journal of Pharmaceutical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciftci, Osman</au><au>Duman, Ahmet Sefa</au><au>Turkmen, Neşe Basak</au><au>Taslıdere, Aslı</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats</atitle><jtitle>Brazilian Journal of Pharmaceutical Sciences</jtitle><addtitle>Braz. J. Pharm. Sci</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>54</volume><issue>3</issue><issn>2175-9790</issn><issn>1984-8250</issn><eissn>2175-9790</eissn><abstract>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.</abstract><cop>Sao Paulo</cop><pub>Universidade de Sao Paulo Faculdade de Ciencias</pub><doi>10.1590/s2175-97902018000317674</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2175-9790
ispartof Brazilian Journal of Pharmaceutical Sciences, 2018-01, Vol.54 (3)
issn 2175-9790
1984-8250
2175-9790
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_2f0a7669f02a462aa2f42d5c2542f2df
source Publicly Available Content (ProQuest); SciELO
subjects 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
Antioxidants
Beta-glucan/protective effects
Cardiotoxicity
Enzymes
Heart
Laboratory animals
Lipid peroxidation
Lipids
Oxidative stress
PHARMACOLOGY & PHARMACY
Proteins
Rats
Statistical analysis
title Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T12%3A36%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Beta-glucan%20prevents%20toxic%20effects%20of%202,3,7,8-TCDD%20in%20terms%20of%20oxidative%20and%20histopathological%20damage%20in%20heart%20tissue%20of%20rats&rft.jtitle=Brazilian%20Journal%20of%20Pharmaceutical%20Sciences&rft.au=Ciftci,%20Osman&rft.date=2018-01-01&rft.volume=54&rft.issue=3&rft.issn=2175-9790&rft.eissn=2175-9790&rft_id=info:doi/10.1590/s2175-97902018000317674&rft_dat=%3Cproquest_doaj_%3E2484238623%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c439t-9afb95f381784fab26fed32537d954cbd695d3c6861d2578745981d85211dc763%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2484238623&rft_id=info:pmid/&rft_scielo_id=S1984_82502018000300623&rfr_iscdi=true