Sex-Specific Influence of the SCARB1 Rs5888 SNP on the Serum Lipid Response to Atorvastatin in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Epidemiological studies have shown that there are sex differences in blood lipid levels and lipid responses to statins. Previous studies have shown that the rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 ( ) gene is associated with serum lipid levels in a sex-sp...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine 2020-01, Vol.13, p.553-561
Main Authors: Wu, Dong-Feng, Lin, Dan, Lu, Feng, Liao, Qin-Chen, Wu, Yu-Juan, Wang, Zhou, Yu, Kun, Li, Wei-Jun, Deng, Jin-Long
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Alleles
Angioplasty
Apolipoproteins
Atorvastatin
Cardiovascular disease
Cholesterol
coronary artery disease
Epidemiology
Females
Gender differences
Gene polymorphism
Genotyping
High density lipoprotein
lipid
Lipids
Low density lipoprotein
Males
Original Research
Polymerase chain reaction
polymorphism
scavenger receptor class b type 1
Scavenger receptors
Sex
Sex differences
sex-specific
Single-nucleotide polymorphism
Statins
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Summary:Epidemiological studies have shown that there are sex differences in blood lipid levels and lipid responses to statins. Previous studies have shown that the rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 ( ) gene is associated with serum lipid levels in a sex-specific manner. The present study was undertaken to detect the sex-specific influence of the rs5888 SNP on the serum lipid response to atorvastatin in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). A total of 158 unrelated ACS patients (108 males, 50 females) were enrolled, and all patients received atorvastatin 20 mg/daily after PCI. Genotyping of the rs5888 SNP was performed by polymerase chain reaction and direct sequencing. Serum lipid profiles were determined before treatment and after an average follow-up time of one year. The baseline serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (Apo)AI levels were higher in females than in males (P
ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S273346