Clinical Significance of Tie-2-Expressing Monocytes/Macrophages and Angiopoietins in the Progression of Ovarian Cancer-State-of-the-Art

Tumour growth and metastasis are specific to advanced stages of epithelial ovarian cancer (EOC). Tumour angiogenesis is an essential part of these processes. It is responsible for providing tumours with nutrients, metabolites, and cytokines and facilitates tumour and immune cell relocation. Destabil...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-11, Vol.11 (23), p.3851
Main Authors: Skiba, Wiktoria, Suszczyk, Dorota, Pawłowska, Anna, Włodarczyk, Karolina, Pańczyszyn, Anna, Wertel, Iwona
Format: Article
Language:English
Subjects:
Abdomen
Angiogenesis
angiopoietins
Angiopoietins - metabolism
Blood vessels
Carcinoma, Ovarian Epithelial
Cell receptors
Clinical Relevance
Clinical significance
Cytokines
Development and progression
Drug delivery
Female
Growth factors
Health aspects
Humans
Hypoxia
Macrophages
Metastases
Metastasis
Microenvironments
Monocytes
Neovascularization, Pathologic - metabolism
Ovarian cancer
Ovarian Neoplasms - metabolism
Permeability
Receptor, TIE-2 - metabolism
Review
Stem cells
Tie-2-expressing monocytes
Tumor Microenvironment
Tumor necrosis factor-TNF
Tumors
tumour microenvironment
Vascular endothelial growth factor
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tumour growth and metastasis are specific to advanced stages of epithelial ovarian cancer (EOC). Tumour angiogenesis is an essential part of these processes. It is responsible for providing tumours with nutrients, metabolites, and cytokines and facilitates tumour and immune cell relocation. Destabilised vasculature, a distinctive feature of tumours, is also responsible for compromising drug delivery into the bulk. Angiogenesis is a complex process that largely depends on how the tumour microenvironment (TME) is composed and how a specific organ is formed. There are contrary reports on whether Tie-2-expressing monocytes/macrophages (TEMs) reported as the proangiogenic population of monocytes have any impact on tumour development. The aim of this paper is to summarise knowledge about ovarian-cancer-specific angiogenesis and the unique role of Tie-2-expressing monocytes/macrophages in this process. The significance of this cell subpopulation for the pathophysiology of EOC remains to be investigated.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11233851