Epidemiological characteristics, diagnosis and treatment effect of rifampicin-resistant pulmonary tuberculosis (RR-PTB) in Guizhou Province

• Published in: BMC infectious diseases 2024-09, Vol.24 (1), p.1058-11, Article 1058
• Main Authors: Zhou, Jian, Li, Jinlan, Hu, Yong, Li, Shijun
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Antitubercular Agents - therapeutic use; Child; China - epidemiology; Clinical outcomes; Diagnosis; Diagnosis and treatment; Diagnostic systems; Disease prevention; Drug resistance; Drug resistance in microorganisms; Environmental factors; Epidemiology; Ethics; Female; Females; Gender; Global health; Housework; Humans; Information systems; Male; Males; Medical diagnosis; Medical research; Medicine, Experimental; Melting curve; Middle Aged; Minority & ethnic groups; Morbidity; Mutation; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Patient outcomes; Population characteristics; Public health; Pulmonary tuberculosis; Ratios; Real time; Registration; Resource allocation; Rifampicin-resistant pulmonary tuberculosis; Rifampin; Rifampin - therapeutic use; Risk factors; Social interactions; Spatial distribution; Spatio-temporal distribution; Statistical analysis; Support systems; Temporal distribution; Trends; Tuberculosis; Tuberculosis, Multidrug-Resistant - diagnosis; Tuberculosis, Multidrug-Resistant - drug therapy; Tuberculosis, Multidrug-Resistant - epidemiology; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - microbiology; Western China; Young Adult
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-024-09976-9

Rifampicin-resistant pulmonary tuberculosis (RR-PTB) presents a significant threat to global public health security. China bears a substantial burden of RR-PTB cases globally, with Guizhou Province experiencing particularly alarming trends, marked by a continual increase in patient numbers. Understanding the population characteristics and treatment modalities for RR-PTB is crucial for mitigating morbidity and mortality associated with this disease. We gathered epidemiological, diagnostic, and treatment data of all RR-PTB cases recorded in Guizhou Province from January 1, 2017 to December 31, 2023. Utilizing composition ratios as the analytical metric, we employed Chi-square tests to examine the spatiotemporal distribution patterns of RR-PTB patients and the evolving trends among different patient classifications over the study period. In our study, 3396 cases of RR-PTB were analyzed, with an average age of 45 years. The number of RR-PTB patients rose significantly from 176 in 2017 to 960 in 2023, peaking notably among individuals aged 23-28 and 44-54, with a rising proportion in the 51-80 age group (P