Effect of strontium doping on the biocompatibility of calcium phosphate-coated titanium substrates

Background: Titanium biomedical devices coated with strontium-doped calcium phosphate ceramics can support desirable bone regeneration through anabolic and anti-catabolic effects of strontium and the compositions close to that of natural mineral tissue. Methods: Strontium was doped into the calcium...

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Bibliographic Details
Published in:Journal of applied biomaterials & functional materials 2019-01, Vol.17 (1), p.2280800019826517-2280800019826517
Main Authors: Nguyen, Thuy-Duong Thi, Jang, Yong-Seok, Lee, Min-Ho, Bae, Tae-Sung
Format: Article
Language:English
Subjects:
Biocompatibility
Bone growth
Calcification
Calcium
Calcium phosphates
Cell adhesion
Cell adhesion & migration
Ceramic coatings
Chemical composition
Coatings
Doping
Metal plates
Morphology
Phosphate
Phosphate coatings
Regeneration
Regeneration (physiology)
Strontium
Substrates
Surgical implants
Titanium
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Summary:Background: Titanium biomedical devices coated with strontium-doped calcium phosphate ceramics can support desirable bone regeneration through anabolic and anti-catabolic effects of strontium and the compositions close to that of natural mineral tissue. Methods: Strontium was doped into the calcium phosphate coating using the cyclic pre-calcification method on the anodized titanium plate. The effects of the different concentration of strontium in treatment solution and cycle numbers of the pre-calcification treatment on the biocompatibility were investigated in terms of the changes in morphology and chemical composition of coating, ion release pattern and cytocompatibility in vitro. Results: At a high substitution ratio of strontium in the calcium phosphate coating, the size of precipitated particles was decreased and the solubility of the coating was increased. ASH55 group, which was coated by pre-calcification treatment of 20 cycles in coating solution with Sr:Ca molar ratio of 5:5, exhibited superior cellular attachment at 1 day and proliferation after 7 days of culturing in comparison with the non-doped surface and other doped surfaces. Conclusion: Sufficient strontium doping concentrations in calcium phosphate coating can enhance cell adhesion and proliferation on the titanium biomedical devices for bone regeneration.
ISSN:2280-8000
2280-8000
DOI:10.1177/2280800019826517