Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammator...

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Bibliographic Details
Published in:Pharmaceutics 2022-12, Vol.15 (1), p.77
Main Authors: Parfenyuk, Elena, Dolinina, Ekaterina
Format: Article
Language:English
Subjects:
anti-inflammatory drug
Arthritis
Biodegradable materials
biodegradation
colloid silica
Cosmetics
Deformation
drug delivery
Drug delivery systems
Enzymes
Hyaluronic acid
hydrogel
Hydrogels
Investigations
Mechanical properties
Molecular weight
Nanoparticles
Polymers
Skin diseases
Tissue engineering
Viscoelasticity
Viscosity
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Summary:Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol-gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15010077