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Production of vegetable oil blends and structured lipids and their effect on wound healing
Two oil blends (sunflower/canola oils 85/15 (BL1) and canola/linseed oils 70/30 (BL2)), were prepared and enzymatically interesterified to be applied to surgically-induced wounds in rats. Following surgery, the animals were submitted to the Treatment with Physiological Saline (TPS) (control group),...
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| Published in: | Brazilian Journal of Pharmaceutical Sciences 2015-06, Vol.51 (2), p.415-427 |
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| container_end_page | 427 |
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| container_title | Brazilian Journal of Pharmaceutical Sciences |
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| creator | Ract, Juliana Neves Rodrigues Soares, Fabiana Andreia Schäfer De Martini Rodrigues, Hosana Gomes Bortolon, José Ricardo Murata, Gilson Masahiro Gonçalves, Maria Inês Almeida Hatanaka, Elaine Curi, Rui Gioielli, Luiz Antonio |
| description | Two oil blends (sunflower/canola oils 85/15 (BL1) and canola/linseed oils 70/30 (BL2)), were prepared and enzymatically interesterified to be applied to surgically-induced wounds in rats. Following surgery, the animals were submitted to the Treatment with Physiological Saline (TPS) (control group), Blends (TBL), and Structured Lipids (TSL). The control group (TPS) received physiological saline solution for 15 days. In TBL, BL1 was administered during the inflammation phase (days 0-3) and BL2 in the tissue formation and remodeling phase (days 4-15). In TSL, Structured Lipid 1 (SL1) and Structured Lipid 2 (SL2) were used instead of BL1 and BL2, respectively. The aim of this study was to compare wound closure evolution among rats treated with the blends or structured lipids versus control rats treated with physiological saline. The wound healing process was evaluated by measuring the wound areas along the treatments and the concentrations of cytokines. An increase in the areas of wounds treated with the blends and structured lipids in the inflammatory phase was observed, followed by a steeper closure curve compared to wounds treated with physiological saline. The changes observed during the inflammatory phase suggest a potential therapeutic application in cutaneous wound healing which should be further investigated.
Duas misturas de óleos vegetais (girassol/canola 85/15 (BL1) e canola/linhaça, 70/30 (BL2) foram preparadas e interesterificadas por via enzimática para serem aplicadas em feridas induzidas cirurgicamente em ratos. Após a cirurgia, os animais foram submetidos ao tratamento com soro fisiológico (TPS) (grupo controle), tratamento com as misturas (TBL) e tratamento com os lipídios estruturados (TSL). O grupo controle (TPS) recebeu soro fisiológico por 15 dias. Em TBL, BL1 foi administrada durante a fase de inflamação (dias 0-3) e BL2 na fase de formação de tecido e remodelação (dias 4-15). Em TSL, os lipídios estruturados SL1 e SL2 foram usados em vez de BL1 e BL2, respectivamente. O objetivo deste estudo foi avaliar a evolução do fechamento das feridas dos grupos de ratos tratados com as misturas ou lipídios estruturados em comparação com os ratos do grupo controle, tratados com soro fisiológico. O processo de cicatrização das feridas foi avaliado através da medição das áreas das feridas ao longo dos tratamentos e pela determinação das concentrações de citocinas. Observou-se aumento das áreas das feridas tratadas com as misturas e os lipídios estrut |
| doi_str_mv | 10.1590/S1984-82502015000200019 |
| format | article |
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Duas misturas de óleos vegetais (girassol/canola 85/15 (BL1) e canola/linhaça, 70/30 (BL2) foram preparadas e interesterificadas por via enzimática para serem aplicadas em feridas induzidas cirurgicamente em ratos. Após a cirurgia, os animais foram submetidos ao tratamento com soro fisiológico (TPS) (grupo controle), tratamento com as misturas (TBL) e tratamento com os lipídios estruturados (TSL). O grupo controle (TPS) recebeu soro fisiológico por 15 dias. Em TBL, BL1 foi administrada durante a fase de inflamação (dias 0-3) e BL2 na fase de formação de tecido e remodelação (dias 4-15). Em TSL, os lipídios estruturados SL1 e SL2 foram usados em vez de BL1 e BL2, respectivamente. O objetivo deste estudo foi avaliar a evolução do fechamento das feridas dos grupos de ratos tratados com as misturas ou lipídios estruturados em comparação com os ratos do grupo controle, tratados com soro fisiológico. O processo de cicatrização das feridas foi avaliado através da medição das áreas das feridas ao longo dos tratamentos e pela determinação das concentrações de citocinas. Observou-se aumento das áreas das feridas tratadas com as misturas e os lipídios estruturados na fase inflamatória, seguida por um fechamento acentuado de feridas comparado com o tratamento com solução salina. As mudanças observadas durante a fase inflamatória sugerem uma potencial aplicação terapêutica na cicatrização de feridas cutâneas, fazendo-se necessárias investigações posteriores.</description><identifier>ISSN: 1984-8250</identifier><identifier>ISSN: 2175-9790</identifier><identifier>EISSN: 1984-8250</identifier><identifier>DOI: 10.1590/S1984-82502015000200019</identifier><language>eng</language><publisher>Universidade de São Paulo, Faculdade de Ciências Farmacêuticas</publisher><subject>Cicatrização ; Feridas cutâneas/cicatrização/tratamento ; Lipídio estruturado/efeito/cicatrização de feridas ; PHARMACOLOGY & PHARMACY ; Óleo vegetal/efeito/cicatrização de feridas</subject><ispartof>Brazilian Journal of Pharmaceutical Sciences, 2015-06, Vol.51 (2), p.415-427</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c7e4e960ec3e344097b788b0747b5059b1f4e0f46ff9bb2b4a4db2a3ae2d725b3</citedby><cites>FETCH-LOGICAL-c465t-c7e4e960ec3e344097b788b0747b5059b1f4e0f46ff9bb2b4a4db2a3ae2d725b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>Ract, Juliana Neves Rodrigues</creatorcontrib><creatorcontrib>Soares, Fabiana Andreia Schäfer De Martini</creatorcontrib><creatorcontrib>Rodrigues, Hosana Gomes</creatorcontrib><creatorcontrib>Bortolon, José Ricardo</creatorcontrib><creatorcontrib>Murata, Gilson Masahiro</creatorcontrib><creatorcontrib>Gonçalves, Maria Inês Almeida</creatorcontrib><creatorcontrib>Hatanaka, Elaine</creatorcontrib><creatorcontrib>Curi, Rui</creatorcontrib><creatorcontrib>Gioielli, Luiz Antonio</creatorcontrib><title>Production of vegetable oil blends and structured lipids and their effect on wound healing</title><title>Brazilian Journal of Pharmaceutical Sciences</title><addtitle>Braz. J. Pharm. Sci</addtitle><description>Two oil blends (sunflower/canola oils 85/15 (BL1) and canola/linseed oils 70/30 (BL2)), were prepared and enzymatically interesterified to be applied to surgically-induced wounds in rats. Following surgery, the animals were submitted to the Treatment with Physiological Saline (TPS) (control group), Blends (TBL), and Structured Lipids (TSL). The control group (TPS) received physiological saline solution for 15 days. In TBL, BL1 was administered during the inflammation phase (days 0-3) and BL2 in the tissue formation and remodeling phase (days 4-15). In TSL, Structured Lipid 1 (SL1) and Structured Lipid 2 (SL2) were used instead of BL1 and BL2, respectively. The aim of this study was to compare wound closure evolution among rats treated with the blends or structured lipids versus control rats treated with physiological saline. The wound healing process was evaluated by measuring the wound areas along the treatments and the concentrations of cytokines. An increase in the areas of wounds treated with the blends and structured lipids in the inflammatory phase was observed, followed by a steeper closure curve compared to wounds treated with physiological saline. The changes observed during the inflammatory phase suggest a potential therapeutic application in cutaneous wound healing which should be further investigated.
Duas misturas de óleos vegetais (girassol/canola 85/15 (BL1) e canola/linhaça, 70/30 (BL2) foram preparadas e interesterificadas por via enzimática para serem aplicadas em feridas induzidas cirurgicamente em ratos. Após a cirurgia, os animais foram submetidos ao tratamento com soro fisiológico (TPS) (grupo controle), tratamento com as misturas (TBL) e tratamento com os lipídios estruturados (TSL). O grupo controle (TPS) recebeu soro fisiológico por 15 dias. Em TBL, BL1 foi administrada durante a fase de inflamação (dias 0-3) e BL2 na fase de formação de tecido e remodelação (dias 4-15). Em TSL, os lipídios estruturados SL1 e SL2 foram usados em vez de BL1 e BL2, respectivamente. O objetivo deste estudo foi avaliar a evolução do fechamento das feridas dos grupos de ratos tratados com as misturas ou lipídios estruturados em comparação com os ratos do grupo controle, tratados com soro fisiológico. O processo de cicatrização das feridas foi avaliado através da medição das áreas das feridas ao longo dos tratamentos e pela determinação das concentrações de citocinas. Observou-se aumento das áreas das feridas tratadas com as misturas e os lipídios estruturados na fase inflamatória, seguida por um fechamento acentuado de feridas comparado com o tratamento com solução salina. As mudanças observadas durante a fase inflamatória sugerem uma potencial aplicação terapêutica na cicatrização de feridas cutâneas, fazendo-se necessárias investigações posteriores.</description><subject>Cicatrização</subject><subject>Feridas cutâneas/cicatrização/tratamento</subject><subject>Lipídio estruturado/efeito/cicatrização de feridas</subject><subject>PHARMACOLOGY & PHARMACY</subject><subject>Óleo vegetal/efeito/cicatrização de feridas</subject><issn>1984-8250</issn><issn>2175-9790</issn><issn>1984-8250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkdtKAzEQhhdRsNQ-g3mBrckmaTaXUjwUCgrqjTchh0mbsm5Kdlfx7U0PFAWv_vBn_m-GmaK4JnhKuMQ3L0TWrKwrjitMOMZZMCbyrBidPs5_vS-LSddtdiWc1ZLxUfH-nKIbbB9ii6JHn7CCXpsGUAwNytq6DunWoa5PuWpI4FATtuHo9msICYH3YHuUCV9xyO4adBPa1VVx4XXTweSo4-Lt_u51_lgunx4W89tladmM96UVwEDOMFgKlDEshRF1bbBgwnDMpSGeAfZs5r00pjJMM2cqTTVUTlTc0HGxOHBd1Bu1TeFDp28VdVB7I6aV0qkPtgFVZYwGTwShhlGfu2hCOa8c55hZzTNremB1NkAT1SYOqc3Dq_2i1d9FM7ILiEPApth1CfxpAILV7kT_JvOJ6A-HrIGl</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Ract, Juliana Neves Rodrigues</creator><creator>Soares, Fabiana Andreia Schäfer De Martini</creator><creator>Rodrigues, Hosana Gomes</creator><creator>Bortolon, José Ricardo</creator><creator>Murata, Gilson Masahiro</creator><creator>Gonçalves, Maria Inês Almeida</creator><creator>Hatanaka, Elaine</creator><creator>Curi, Rui</creator><creator>Gioielli, Luiz Antonio</creator><general>Universidade de São Paulo, Faculdade de Ciências Farmacêuticas</general><general>Universidade de São Paulo</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>20150601</creationdate><title>Production of vegetable oil blends and structured lipids and their effect on wound healing</title><author>Ract, Juliana Neves Rodrigues ; Soares, Fabiana Andreia Schäfer De Martini ; Rodrigues, Hosana Gomes ; Bortolon, José Ricardo ; Murata, Gilson Masahiro ; Gonçalves, Maria Inês Almeida ; Hatanaka, Elaine ; Curi, Rui ; Gioielli, Luiz Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-c7e4e960ec3e344097b788b0747b5059b1f4e0f46ff9bb2b4a4db2a3ae2d725b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cicatrização</topic><topic>Feridas cutâneas/cicatrização/tratamento</topic><topic>Lipídio estruturado/efeito/cicatrização de feridas</topic><topic>PHARMACOLOGY & PHARMACY</topic><topic>Óleo vegetal/efeito/cicatrização de feridas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ract, Juliana Neves Rodrigues</creatorcontrib><creatorcontrib>Soares, Fabiana Andreia Schäfer De Martini</creatorcontrib><creatorcontrib>Rodrigues, Hosana Gomes</creatorcontrib><creatorcontrib>Bortolon, José Ricardo</creatorcontrib><creatorcontrib>Murata, Gilson Masahiro</creatorcontrib><creatorcontrib>Gonçalves, Maria Inês Almeida</creatorcontrib><creatorcontrib>Hatanaka, Elaine</creatorcontrib><creatorcontrib>Curi, Rui</creatorcontrib><creatorcontrib>Gioielli, Luiz Antonio</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><collection>Directory of Open Access Journals(OpenAccess)</collection><jtitle>Brazilian Journal of Pharmaceutical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ract, Juliana Neves Rodrigues</au><au>Soares, Fabiana Andreia Schäfer De Martini</au><au>Rodrigues, Hosana Gomes</au><au>Bortolon, José Ricardo</au><au>Murata, Gilson Masahiro</au><au>Gonçalves, Maria Inês Almeida</au><au>Hatanaka, Elaine</au><au>Curi, Rui</au><au>Gioielli, Luiz Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of vegetable oil blends and structured lipids and their effect on wound healing</atitle><jtitle>Brazilian Journal of Pharmaceutical Sciences</jtitle><addtitle>Braz. J. Pharm. Sci</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>51</volume><issue>2</issue><spage>415</spage><epage>427</epage><pages>415-427</pages><issn>1984-8250</issn><issn>2175-9790</issn><eissn>1984-8250</eissn><abstract>Two oil blends (sunflower/canola oils 85/15 (BL1) and canola/linseed oils 70/30 (BL2)), were prepared and enzymatically interesterified to be applied to surgically-induced wounds in rats. Following surgery, the animals were submitted to the Treatment with Physiological Saline (TPS) (control group), Blends (TBL), and Structured Lipids (TSL). The control group (TPS) received physiological saline solution for 15 days. In TBL, BL1 was administered during the inflammation phase (days 0-3) and BL2 in the tissue formation and remodeling phase (days 4-15). In TSL, Structured Lipid 1 (SL1) and Structured Lipid 2 (SL2) were used instead of BL1 and BL2, respectively. The aim of this study was to compare wound closure evolution among rats treated with the blends or structured lipids versus control rats treated with physiological saline. The wound healing process was evaluated by measuring the wound areas along the treatments and the concentrations of cytokines. An increase in the areas of wounds treated with the blends and structured lipids in the inflammatory phase was observed, followed by a steeper closure curve compared to wounds treated with physiological saline. The changes observed during the inflammatory phase suggest a potential therapeutic application in cutaneous wound healing which should be further investigated.
Duas misturas de óleos vegetais (girassol/canola 85/15 (BL1) e canola/linhaça, 70/30 (BL2) foram preparadas e interesterificadas por via enzimática para serem aplicadas em feridas induzidas cirurgicamente em ratos. Após a cirurgia, os animais foram submetidos ao tratamento com soro fisiológico (TPS) (grupo controle), tratamento com as misturas (TBL) e tratamento com os lipídios estruturados (TSL). O grupo controle (TPS) recebeu soro fisiológico por 15 dias. Em TBL, BL1 foi administrada durante a fase de inflamação (dias 0-3) e BL2 na fase de formação de tecido e remodelação (dias 4-15). Em TSL, os lipídios estruturados SL1 e SL2 foram usados em vez de BL1 e BL2, respectivamente. O objetivo deste estudo foi avaliar a evolução do fechamento das feridas dos grupos de ratos tratados com as misturas ou lipídios estruturados em comparação com os ratos do grupo controle, tratados com soro fisiológico. O processo de cicatrização das feridas foi avaliado através da medição das áreas das feridas ao longo dos tratamentos e pela determinação das concentrações de citocinas. Observou-se aumento das áreas das feridas tratadas com as misturas e os lipídios estruturados na fase inflamatória, seguida por um fechamento acentuado de feridas comparado com o tratamento com solução salina. As mudanças observadas durante a fase inflamatória sugerem uma potencial aplicação terapêutica na cicatrização de feridas cutâneas, fazendo-se necessárias investigações posteriores.</abstract><pub>Universidade de São Paulo, Faculdade de Ciências Farmacêuticas</pub><doi>10.1590/S1984-82502015000200019</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brazilian Journal of Pharmaceutical Sciences, 2015-06, Vol.51 (2), p.415-427 |
| issn | 1984-8250 2175-9790 1984-8250 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_2f46aef1713b43f8b0a13552d5504ca5 |
| source | SciELO |
| subjects | Cicatrização Feridas cutâneas/cicatrização/tratamento Lipídio estruturado/efeito/cicatrização de feridas PHARMACOLOGY & PHARMACY Óleo vegetal/efeito/cicatrização de feridas |
| title | Production of vegetable oil blends and structured lipids and their effect on wound healing |
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