Whole-genome sequencing data of Corynebacterium diphtheriae isolated from diphtheria outbreaks in Indonesia

Corynebacterium diphtheriae (C. diphtheriae) is the causative agent of diphtheria. The main virulence factor of C. diphtheriae is diphtheria toxin, which is encoded by the tox gene and regulated by the dtxR gene. The tox and dtxR genes are used as genetic markers to identify bacteria causing diphthe...

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Bibliographic Details
Published in:Data in brief 2022-08, Vol.43, p.108460-108460, Article 108460
Main Authors: Setiawaty, Vivi, Puspandari, Nelly, Saraswati, Ratih Dian, Febriyana, Dwi, Febrianti, Tati, Rukminiati, Yuni, Muna, Fauzul, Fitriana, Fitriana, Safari, Dodi, Pratama, Rahadian, Lienggonegoro, Lisa Andriani, Sunarno, Sunarno
Format: Article
Language:English
Subjects:
Corynebacterium diphtheriae
Data
Diphtheria outbreak
Indonesia
Whole-genome sequencing
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Summary:Corynebacterium diphtheriae (C. diphtheriae) is the causative agent of diphtheria. The main virulence factor of C. diphtheriae is diphtheria toxin, which is encoded by the tox gene and regulated by the dtxR gene. The tox and dtxR genes are used as genetic markers to identify bacteria causing diphtheria by PCR. Here, we present the whole-genome sequencing (WGS) data of 18 C. diphtheriae isolates from diphtheria outbreaks in different regions in Indonesia. We used these data to identify single nucleotide polymorphisms (SNPs) associated with the tox and dtxR genes to verify the accuracy of the PCR assay and performed molecular typing with a multilocus sequence typing (MLST) approach. The data can be used for further analyses, such as antimicrobial resistance and bacterial virulence factors.
ISSN:2352-3409
2352-3409
DOI:10.1016/j.dib.2022.108460