The underused potential of breast conserving therapy after neoadjuvant system treatment – Causes and solutions

• Published in: Breast (Edinburgh) 2023-02, Vol.67, p.110-115
• Main Authors: Pfob, André, Dubsky, Peter
• Format: Article
• Language: English
• Subjects: (s) from the Special Issue on: De-escalation of loco-regional treatment; Edited by Oreste Gentilini, Philip Poortmans, Maria João Cardoso, Elzbieta Senkus-Konefka; Breast conserving therapy; Breast Neoplasms - drug therapy; Breast Neoplasms - surgery; Female; Health equity; Humans; Mastectomy; Mastectomy, Segmental; Neoadjuvant systemic treatment; Neoadjuvant Therapy
• ISSN: 0960-9776; 1532-3080
• DOI: 10.1016/j.breast.2023.01.008

Breast conserving therapy (BCT), consisting of breast conserving surgery and subsequent radiotherapy, is an equivalent option to mastectomy for women with early breast cancer. Although BCT after neoadjuvant systemic treatment (NAST) has been routinely recommend by international guidelines since many years, the rate of BCT worldwide varies largely and its potential is still underused. While the rate of BCT in western countries has increased over the past decades to currently about 70%, the rate of BCT is as low as 10% in other countries. In this review, we will evaluate the underused potential of breast conservation after NAST, identify causes, and discuss possible solutions. We identified clinical and non-clinical causes for the underuse of BCT after NAST including uncertainties within the community regarding oncologic outcomes, the correct tumor localization after NAST, the management of multifocal and multicentric tumors, margin assessment, disparities of socio-economic aspects on a patient and national level, and psychological biases affecting the shared decision-making process between patients and clinicians. Possible solutions to mitigate the underuse of BCT after NAST include interdisciplinary teams that keep the whole patient pathway in mind, optimized treatment counseling and shared decision-making, and targeted financial support to alleviate disparities. •Breast conserving therapy requires complex, multidisciplinary teamwork.•We identified reasons for its underuse after neoadjuvant treatment.•Clinical, socio-economic, and psychological factors were identified.•Solutions include interdisciplinary teams, optimized counseling, financial support.