Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis

Background. Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status’ association with bone mineral density evaluated by dual X-ray absorptiometry scan...

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Bibliographic Details
Published in:International journal of endocrinology 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Hitz, Mette Friberg, Skov, Marianne, Katzenstein, Terese Lea, Oturai, Peter, Pressler, Tacjana, Mathiesen, Inger Hee, Frikke-Schmidt, Ruth
Format: Article
Language:English
Subjects:
Adults
Age
Alfacalcidol
Body mass index
Bone density
Calcifediol
Comparative analysis
Creatinine
Cystic fibrosis
Diabetes
Endocrinology
Fractures
Gender
Glycosylated hemoglobin
Health aspects
Infections
Metabolism
Osteoporosis
Phosphatase
Physiological aspects
Testosterone
Vitamin D
Vitamin deficiency
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Summary:Background. Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status’ association with bone mineral density evaluated by dual X-ray absorptiometry scan. Methods. We performed a cross section database study of adults at a tertiary CF Center. Z scores were applied for patients  50 years of age. Results. One hundred twenty-five patients were included. Compared to nonosteoporotic patients, osteoporotic patients (15%) had significantly lower percent predicted forced expiratory volume in 1 second (ppFEV1), lower body mass index, higher frequency of CF-related diabetes and chronic lung infection, and higher high-sensitive C-reactive protein and glycated hemoglobin levels. Vitamin D was not associated with any outcome. In multivariate analyses, only ppFEV1 and female gender were independently associated with Z scores. Conclusions. Osteoporosis in CF occurs with deteriorating clinical status while the role of calcium metabolism seems minor. Gender specific and dysglycemic impact on bone status should be investigated further.
ISSN:1687-8337
1687-8345
DOI:10.1155/2018/4803974