Different expression and prognostic value of troponin in ischemic cardiomyopathy and non-ischemic dilated cardiomyopathy

Early risk stratification of patients with ischemic cardiomyopathy (ICM) and non-ischemic dilated cardiomyopathy (NIDCM) may be beneficial for therapies. We retrospectively enrolled all patients admitted for acute heart failure (HF) between January 2019 and December 2021 in Zhongshan Hospital Fudan...

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Published in:European journal of medical research 2023-07, Vol.28 (1), p.220-220, Article 220
Main Authors: Gao, Wei, Zhang, Meng, Song, Yu, Han, Xueting, Xu, Yamei, Zhou, Jingmin, Ge, Junbo
Format: Article
Language:English
Subjects:
Cardiac troponin
Cardiomyopathy
Cardiomyopathy, Dilated
Cardiomyopathy, Dilated - complications
Comparative analysis
Development and progression
Ejection fraction
Heart failure
Heart Failure - complications
Hospital patients
Humans
Ischemia
Ischemic cardiomyopathy
Medical imaging
Mortality
Myocardial Ischemia - complications
Non-ischemic dilated cardiomyopathy
Patients
Prognosis
Regression analysis
Retrospective Studies
Risk factors
Troponin
Troponin T
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Summary:Early risk stratification of patients with ischemic cardiomyopathy (ICM) and non-ischemic dilated cardiomyopathy (NIDCM) may be beneficial for therapies. We retrospectively enrolled all patients admitted for acute heart failure (HF) between January 2019 and December 2021 in Zhongshan Hospital Fudan University, dividing them according to etiology (ICM or NIDCM). Cardiac troponin T (TNT) concentration was compared between two groups. Risk factors for positive TNT and in-hospital all-cause mortality were investigated with regression analysis. A total of 1525 HF patients were enrolled, including 571 ICM and 954 NIDCM. The TNT positive patients were not different between the two groups (41.3% in ICM group vs. 37.8% in NIDCM group, P = 0.215). However, the TNT value in ICM group were significantly higher than that in NIDCM group (0.025 (0.015-0.053) vs. 0.020 (0.014-0.041), P = 0.001). NT-proBNP was independently associated with TNT in both ICM and NIDCM group. Although the in-hospital all-cause mortality did not show much difference between the two groups (1.1% vs. 1.9%, P = 0.204), the NIDCM diagnosis was associated with reduced risk of mortality after multiple adjustments (OR 0.169, 95% CI 0.040-0.718, P = 0.016). Other independent risk factors included the level of NT-proBNP (OR 8.260, 95% CI 3.168-21.533, P 
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-023-01169-5