Profiling Mycobacterium ulcerans : sporulation, survival strategy and response to environmental factors

is the causative agent of Buruli ulcer - a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in , it is likely that employs sporulation mechanisms for its survival and transmission. In this review, we mo...

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Bibliographic Details
Published in:Future science OA 2023-03, Vol.9 (3), p.FSO845-FSO845
Main Authors: Ayerakwa, Eunice Ampadubea, Abban, Molly Kukua, Isawumi, Abiola, Mosi, Lydia
Format: Article
Language:English
Subjects:
Buruli ulcer
environmental pathogen
mycobacteria
Mycobacteria ulcerans
Review
sporulation
stress response mechanisms
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Summary:is the causative agent of Buruli ulcer - a necrotizing skin infection. As an environmental pathogen, it has developed stress response mechanisms for survival. Similar to endospore formation in , it is likely that employs sporulation mechanisms for its survival and transmission. In this review, we modeled possible transmission routes and patterns of from the environment to its host. We provided insights into the evolution of and its genomic profiles. We discuss reservoirs of as an environmental pathogen and its environmental survival. We comprehensively discuss sporulation as a possible stress response mechanism and modelled endospore formation in . At last, we highlighted sporulation associated markers, which upon expression trigger endospore formation.
ISSN:2056-5623
2056-5623
DOI:10.2144/fsoa-2022-0044