SARS-CoV-2 and interferon blockade

The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon...

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Bibliographic Details
Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2020-11, Vol.26 (1), p.103-6, Article 103
Main Authors: Diamond, Betty, Volpe, Bruce T, VanPatten, Sonya, Al Abed, Yousef
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Betacoronavirus - immunology
Bradykinin - metabolism
Brain
Coronavirus Infections - immunology
Coronaviruses
COVID-19
Cytokines
Disease transmission
Humans
Hypoxia
Immunity, Innate
Infections
Inflammation
Interferon
Kallikreins - metabolism
Models, Immunological
Neurons
Neutrophils
Pandemics
Pneumonia, Viral - immunology
Renin-Angiotensin System
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral infections
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Summary:The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
ISSN:1076-1551
1528-3658
1528-3658
DOI:10.1186/s10020-020-00231-w