Glucose Uptake and Oxidative Stress in Caco-2 Cells: Health Benefits from Posidonia oceanica (L.) Delile

Posidonia oceanica (L.) Delile is an endemic Mediterranean marine plant of extreme ecological importance. Previous in vitro and in vivo studies have demonstrated the potential antidiabetic properties of P. oceanica leaf extract. Intestinal glucose transporters play a key role in glucose homeostasis...

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Bibliographic Details
Published in:Marine drugs 2022-07, Vol.20 (7), p.457
Main Authors: Morresi, Camilla, Vasarri, Marzia, Bellachioma, Luisa, Ferretti, Gianna, Degl′Innocenti, Donatella, Bacchetti, Tiziana
Format: Article
Language:English
Subjects:
Acids
AGEs
Antidiabetics
Antioxidants
Butyl hydroperoxide
Cells
Chronic exposure
Diabetes
Diabetes mellitus
Endemic plants
Glucose
Glucose transport
Glucose transporter
Homeostasis
In vivo methods and tests
Incubation
Integrity
intestinal barrier integrity
intestinal glucose uptake
Intestine
Investigations
Leaves
marine antioxidants
Marine ecology
Marine plants
Metabolism
Oxidative stress
Plant extracts
Polyphenols
Posidonia oceanica
Proteins
Sodium
Uptake
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Summary:Posidonia oceanica (L.) Delile is an endemic Mediterranean marine plant of extreme ecological importance. Previous in vitro and in vivo studies have demonstrated the potential antidiabetic properties of P. oceanica leaf extract. Intestinal glucose transporters play a key role in glucose homeostasis and represent novel targets for the management of diabetes. In this study, the ability of a hydroalcoholic P. oceanica leaf extract (POE) to modulate intestinal glucose transporters was investigated using Caco-2 cells as a model of an intestinal barrier. The incubation of cells with POE significantly decreased glucose uptake by decreasing the GLUT2 glucose transporter levels. Moreover, POE had a positive effect on the barrier integrity by increasing the Zonulin-1 levels. A protective effect exerted by POE against oxidative stress induced by chronic exposure to high glucose concentrations or tert-butyl hydroperoxide was also demonstrated. This study highlights for the first time the effect of POE on glucose transport, intestinal barrier integrity, and its protective antioxidant effect in Caco-2 cells. These findings suggest that the P. oceanica phytocomplex may have a positive impact by preventing the intestinal cell dysfunction involved in the development of inflammation-related disease associated with oxidative stress.
ISSN:1660-3397
1660-3397
DOI:10.3390/md20070457