Linear IgA and IgG bullous dermatosis

Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 m...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2016-10, Vol.91 (5 suppl 1), p.32-34
Main Authors: Fernandes, Karina de Almeida Pinto, Galvis, Kely Hernández, Gomes, Anndressa Camillo da Matta Setubal, Nogueira, Osvania Maris, Felix, Paulo Antônio Oldani, Vargas, Thiago Jeunon de Sousa
Format: Article
Language:English
Subjects:
Basement membrane
Basement Membrane - pathology
Biopsy
Case Report
Child
DERMATOLOGY
Erythema - pathology
Fluorescent Antibody Technique, Direct
Humans
Immunoglobulin A
Linear IgA bullous dermatosis
Linear IgA Bullous Dermatosis - pathology
Male
Skin - pathology
Skin Diseases, Vesiculobullous - pathology
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Summary:Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
ISSN:0365-0596
1806-4841
1806-4841
0365-0596
DOI:10.1590/abd1806-4841.20164630