Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss

Objective: This study aimed to investigate the serum melatonin levels of patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study enrolled 22 patients with ISSNHL and 22 asymptomatic healthy volunteers. The subjects underwent pure tone audiometry and serum melatonin l...

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Bibliographic Details
Published in:Bezmialem science 2020-07, Vol.8 (3), p.269-274
Main Authors: BAKİ, Ahmet, ÖZER, Ömer Faruk, YILDIZ, Muhammet, KÖKTAŞOĞLU, Fatmanur
Format: Article
Language:English
Subjects:
Age
Antibodies
antioxidant
Antioxidants
Apoptosis
Cytokines
Disease
Ears & hearing
Enzymes
Flow velocity
Free radicals
Hair
Hearing loss
Hypotheses
Laboratories
Melatonin
Metabolites
Otolaryngology
Oxidative stress
Pathogenesis
Patients
Proteins
Statistical analysis
sudden hearing loss
Surgery
Tıp
Viral infections
Womens health
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Summary:Objective: This study aimed to investigate the serum melatonin levels of patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: This study enrolled 22 patients with ISSNHL and 22 asymptomatic healthy volunteers. The subjects underwent pure tone audiometry and serum melatonin levels were measured. Results: The patient group was composed of 12 women (mean age, 46.41±7.8) and 10 men (mean age, 48±6.46), and the control group was composed of 12 women (mean age, 40.25±5.28) and 10 men (mean age, 38.4±27.08). The serum melatonin levels were significantly lower in the patient group than in the control group (p≤0.001). A statistically significant strong negative correlation was found between serum melatonin level and severity of hearing loss (r=−0.644; p=0.001). Conclusion: Serum melatonin levels of patients with ISSNHL were lower than controls. A statistically significant strong negative correlation was found between serum melatonin level and the severity of hearing loss.
ISSN:2148-2373
2148-2373
DOI:10.14235/bas.galenos.2019.3459