Effect of dietary Saccharomyces-derived prebiotic refined functional carbohydrates as antibiotic alternative on growth performance and intestinal health of broiler chickens reared in a commercial farm

• Published in: Poultry science 2023-06, Vol.102 (6), p.102671-102671, Article 102671
• Main Authors: Zhen, Wenrui, Zhu, Ting, Wang, Puhui, Guo, Fangshen, Zhang, Kaichen, Zhang, Tianguo, Jalukar, Sangita, Zhang, Yi, Bai, Dongying, Zhang, Cai, Guo, Yuming, Wang, Zhong, Ma, Yanbo
• Format: Article
• Language: English
• Subjects: Animal Feed - analysis; Animals; Anti-Bacterial Agents - pharmacology; broiler; Chickens - physiology; Diet - veterinary; Dietary Supplements; Farms; growth performance; gut health; IMMUNOLOGY, HEALTH AND DISEASE; Prebiotics; refined functional carbohydrate; Saccharomyces
• ISSN: 0032-5791; 1525-3171
• DOI: 10.1016/j.psj.2023.102671

The search for effective in-feed antibiotic alternative is growing due to the global trend to reduce or ban the utilization of antibiotics as growth promotors in poultry diets. This study was processed to assess the effect of dietary refined functional carbohydrates (RFCs) replacing antibiotic growth promoters (AGP) on growth performance, intestinal morphologic structure and microbiota, as well as intestinal immune function and barrier function of broilers reared on a commercial broilers farm. Trials contained 3 treatments with 4 replicate broiler houses, with about 25,000 birds each room. The treatments were control group (CON), RFCs group (CON + 100 mg/kg RFCs), and AGP group (CON + 50 mg/kg bacitracin methylene disalicylate (BMD), respectively. Results showed that RFCs and AGP group significantly increased (P < 0.05) average daily gain (ADG) during d 22 to 45 in contrast to control. Compared with the control and AGP-treated groups, feeding RFCs increased (P < 0.05) jejunal villus height to crypt depth ratio. AGP addition reduced (P < 0.05) the jejunal villi surface area compared to broilers fed control and RFC supplemented diets. Supplementation of RFCs promoted (P < 0.05) the growth of Lactobacillus but inhibited Escherichia coli and Salmonella proliferation compared with the control group. Inclusion of RFCs and BMD enhanced (P < 0.05) antibody titers against avian influenza virus H9 compared with control. RFCs and AGP both down-regulated (P < 0.05) intestinal TLR4 mRNA levels, whereas RFCs tended to up-regulate (P = 0.05) IFN-γ gene expression compared to control. Expression of intestinal tight junction genes was not affected by either AGP or RFCs supplementation. Based on above observation, we suggested that RFCs could replace in-feed antibiotic BMD in broiler diets for reducing intestinal pathogenic bacteria and modulating immunity of broilers.