Influence of acute renal failure on the mononuclear phagocytic system

Several studies show the ability of macrophages to remove particles injected into the bloodstream. This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the m...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2001-09, Vol.34 (9), p.1169-1174
Main Authors: Sousa, V R, Sousa, A A, Petroianu, A, Simal, C J, Barbosa, A J
Format: Article
Language:English
Subjects:
Acute Kidney Injury - physiopathology
Animals
BIOLOGY
Creatinine - blood
Female
Liver - cytology
Liver - pathology
Liver - physiology
Lung - cytology
Lung - pathology
Lung - physiology
macrophage
Macrophages - physiology
Male
MEDICINE, RESEARCH & EXPERIMENTAL
phagocytosis
Phagocytosis - physiology
Potassium - blood
Rats
Rats, Wistar
renal failure
reticuloendothelial system
scintigraphy
Sodium - blood
Spleen - cytology
Spleen - pathology
Spleen - physiology
Urea - blood
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Summary:Several studies show the ability of macrophages to remove particles injected into the bloodstream. This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the mononuclear phagocytic system in renal and postrenal failures. Fifteen rats (250-350 g) were divided into three groups (N = 5): group I - control; group II - ligature of both ureters, and group III - bilateral nephrectomy. On the third postoperative day, all animals received an iv injection of 1 ml/kg 99mTc sulfur colloid. Blood samples were collected for the assessment of plasma urea, creatinine, sodium, and potassium concentrations and arterial gasometry. Samples of liver, spleen, lung and blood clots were obtained and radioactivity was measured. Samples of liver, spleen, lung and kidney were prepared for routine histopathological analysis. Plasma urea, creatinine and potassium concentrations in groups II and III were higher than in group I (P
ISSN:0100-879X
1414-431X
0100-879X
1414-431X
DOI:10.1590/S0100-879X2001000900010