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Influence of acute renal failure on the mononuclear phagocytic system
Several studies show the ability of macrophages to remove particles injected into the bloodstream. This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the m...
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| Published in: | Brazilian journal of medical and biological research 2001-09, Vol.34 (9), p.1169-1174 |
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| container_title | Brazilian journal of medical and biological research |
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| creator | Sousa, V R Sousa, A A Petroianu, A Simal, C J Barbosa, A J |
| description | Several studies show the ability of macrophages to remove particles injected into the bloodstream. This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the mononuclear phagocytic system in renal and postrenal failures. Fifteen rats (250-350 g) were divided into three groups (N = 5): group I - control; group II - ligature of both ureters, and group III - bilateral nephrectomy. On the third postoperative day, all animals received an iv injection of 1 ml/kg 99mTc sulfur colloid. Blood samples were collected for the assessment of plasma urea, creatinine, sodium, and potassium concentrations and arterial gasometry. Samples of liver, spleen, lung and blood clots were obtained and radioactivity was measured. Samples of liver, spleen, lung and kidney were prepared for routine histopathological analysis. Plasma urea, creatinine and potassium concentrations in groups II and III were higher than in group I (P |
| doi_str_mv | 10.1590/S0100-879X2001000900010 |
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This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the mononuclear phagocytic system in renal and postrenal failures. Fifteen rats (250-350 g) were divided into three groups (N = 5): group I - control; group II - ligature of both ureters, and group III - bilateral nephrectomy. On the third postoperative day, all animals received an iv injection of 1 ml/kg 99mTc sulfur colloid. Blood samples were collected for the assessment of plasma urea, creatinine, sodium, and potassium concentrations and arterial gasometry. Samples of liver, spleen, lung and blood clots were obtained and radioactivity was measured. Samples of liver, spleen, lung and kidney were prepared for routine histopathological analysis. Plasma urea, creatinine and potassium concentrations in groups II and III were higher than in group I (P<0.05). Plasma sodium concentrations in groups II and III were lower than in group I (P<0.05). Compensated metabolic acidosis was observed in the presence of postrenal failure. Group II animals showed a lower level of radioactivity in the spleen (0.98) and lung (2.63), and a higher level in the liver (105.51) than control. Group III animals showed a lower level of radioactivity in the spleen (11.94) and a higher level in the liver (61.80), lung (11.30) and blood clot (5.13) than control. In groups II and III liver steatosis and bronchopneumonia were observed. Renal and postrenal failures seem to interfere with blood clearance by the mononuclear phagocytic system.</description><identifier>ISSN: 0100-879X</identifier><identifier>ISSN: 1414-431X</identifier><identifier>EISSN: 0100-879X</identifier><identifier>EISSN: 1414-431X</identifier><identifier>DOI: 10.1590/S0100-879X2001000900010</identifier><identifier>PMID: 11514841</identifier><language>eng</language><publisher>Brazil: Associação Brasileira de Divulgação Científica</publisher><subject>Acute Kidney Injury - physiopathology ; Animals ; BIOLOGY ; Creatinine - blood ; Female ; Liver - cytology ; Liver - pathology ; Liver - physiology ; Lung - cytology ; Lung - pathology ; Lung - physiology ; macrophage ; Macrophages - physiology ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; phagocytosis ; Phagocytosis - physiology ; Potassium - blood ; Rats ; Rats, Wistar ; renal failure ; reticuloendothelial system ; scintigraphy ; Sodium - blood ; Spleen - cytology ; Spleen - pathology ; Spleen - physiology ; Urea - blood</subject><ispartof>Brazilian journal of medical and biological research, 2001-09, Vol.34 (9), p.1169-1174</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-b952026b3beb9bd3ac3e9787c1a1e236f20943f8b05da93e98587049acf5cc53</citedby><cites>FETCH-LOGICAL-c463t-b952026b3beb9bd3ac3e9787c1a1e236f20943f8b05da93e98587049acf5cc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11514841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sousa, V R</creatorcontrib><creatorcontrib>Sousa, A A</creatorcontrib><creatorcontrib>Petroianu, A</creatorcontrib><creatorcontrib>Simal, C J</creatorcontrib><creatorcontrib>Barbosa, A J</creatorcontrib><title>Influence of acute renal failure on the mononuclear phagocytic system</title><title>Brazilian journal of medical and biological research</title><addtitle>Braz J Med Biol Res</addtitle><description>Several studies show the ability of macrophages to remove particles injected into the bloodstream. This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the mononuclear phagocytic system in renal and postrenal failures. Fifteen rats (250-350 g) were divided into three groups (N = 5): group I - control; group II - ligature of both ureters, and group III - bilateral nephrectomy. On the third postoperative day, all animals received an iv injection of 1 ml/kg 99mTc sulfur colloid. Blood samples were collected for the assessment of plasma urea, creatinine, sodium, and potassium concentrations and arterial gasometry. Samples of liver, spleen, lung and blood clots were obtained and radioactivity was measured. Samples of liver, spleen, lung and kidney were prepared for routine histopathological analysis. Plasma urea, creatinine and potassium concentrations in groups II and III were higher than in group I (P<0.05). Plasma sodium concentrations in groups II and III were lower than in group I (P<0.05). Compensated metabolic acidosis was observed in the presence of postrenal failure. Group II animals showed a lower level of radioactivity in the spleen (0.98) and lung (2.63), and a higher level in the liver (105.51) than control. Group III animals showed a lower level of radioactivity in the spleen (11.94) and a higher level in the liver (61.80), lung (11.30) and blood clot (5.13) than control. In groups II and III liver steatosis and bronchopneumonia were observed. Renal and postrenal failures seem to interfere with blood clearance by the mononuclear phagocytic system.</description><subject>Acute Kidney Injury - physiopathology</subject><subject>Animals</subject><subject>BIOLOGY</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Liver - cytology</subject><subject>Liver - pathology</subject><subject>Liver - physiology</subject><subject>Lung - cytology</subject><subject>Lung - pathology</subject><subject>Lung - physiology</subject><subject>macrophage</subject><subject>Macrophages - physiology</subject><subject>Male</subject><subject>MEDICINE, RESEARCH & EXPERIMENTAL</subject><subject>phagocytosis</subject><subject>Phagocytosis - physiology</subject><subject>Potassium - blood</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>renal failure</subject><subject>reticuloendothelial system</subject><subject>scintigraphy</subject><subject>Sodium - blood</subject><subject>Spleen - cytology</subject><subject>Spleen - pathology</subject><subject>Spleen - physiology</subject><subject>Urea - blood</subject><issn>0100-879X</issn><issn>1414-431X</issn><issn>0100-879X</issn><issn>1414-431X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9UUtvFDEMjhAVLYW_AHPitsV5bSZHVBW6UiUO9NBb5Mk47awykyWZOey_J9tdtUhInGzZ_h62GfvM4YprC19_AQdYtcY-CDikYOEQ37CLl8bbv_Jz9r6ULYDQoPg7ds655qpV_ILdbKYQF5o8NSk06JeZmkwTxibgEJdcy1MzP1EzpilNi4-Eudk94WPy-3nwTdmXmcYP7CxgLPTxFC_Z_feb--vb1d3PH5vrb3crr9ZyXnVWCxDrTnbU2a6X6CVZ0xrPkZOQ6yDAKhnaDnSPtvZa3RpQFn3Q3mt5yTZH2j7h1u3yMGLeu4SDey6k_OgwV1eRnAhoeyOFAr9WvVJoOK-aCgQZIbSpXFdHruIHislt05Lr2sU9n9b9c9oK-HIE7HL6vVCZ3TgUTzHiRGkprgqAbaWog-Y46HMqJVN4ccrBHb73H4lPJ4mlG6l_xZ3eJf8AKZmRsw</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Sousa, V R</creator><creator>Sousa, A A</creator><creator>Petroianu, A</creator><creator>Simal, C J</creator><creator>Barbosa, A J</creator><general>Associação Brasileira de Divulgação Científica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>20010901</creationdate><title>Influence of acute renal failure on the mononuclear phagocytic system</title><author>Sousa, V R ; Sousa, A A ; Petroianu, A ; Simal, C J ; Barbosa, A J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-b952026b3beb9bd3ac3e9787c1a1e236f20943f8b05da93e98587049acf5cc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute Kidney Injury - physiopathology</topic><topic>Animals</topic><topic>BIOLOGY</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Liver - cytology</topic><topic>Liver - pathology</topic><topic>Liver - physiology</topic><topic>Lung - cytology</topic><topic>Lung - pathology</topic><topic>Lung - physiology</topic><topic>macrophage</topic><topic>Macrophages - physiology</topic><topic>Male</topic><topic>MEDICINE, RESEARCH & EXPERIMENTAL</topic><topic>phagocytosis</topic><topic>Phagocytosis - physiology</topic><topic>Potassium - blood</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>renal failure</topic><topic>reticuloendothelial system</topic><topic>scintigraphy</topic><topic>Sodium - blood</topic><topic>Spleen - cytology</topic><topic>Spleen - pathology</topic><topic>Spleen - physiology</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sousa, V R</creatorcontrib><creatorcontrib>Sousa, A A</creatorcontrib><creatorcontrib>Petroianu, A</creatorcontrib><creatorcontrib>Simal, C J</creatorcontrib><creatorcontrib>Barbosa, A J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Brazilian journal of medical and biological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sousa, V R</au><au>Sousa, A A</au><au>Petroianu, A</au><au>Simal, C J</au><au>Barbosa, A J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of acute renal failure on the mononuclear phagocytic system</atitle><jtitle>Brazilian journal of medical and biological research</jtitle><addtitle>Braz J Med Biol Res</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>34</volume><issue>9</issue><spage>1169</spage><epage>1174</epage><pages>1169-1174</pages><issn>0100-879X</issn><issn>1414-431X</issn><eissn>0100-879X</eissn><eissn>1414-431X</eissn><abstract>Several studies show the ability of macrophages to remove particles injected into the bloodstream. This function seems to be increased in the presence of acute renal failure. The objective of the present study was to assess the phagocytic function of the main organs (spleen, liver and lung) of the mononuclear phagocytic system in renal and postrenal failures. Fifteen rats (250-350 g) were divided into three groups (N = 5): group I - control; group II - ligature of both ureters, and group III - bilateral nephrectomy. On the third postoperative day, all animals received an iv injection of 1 ml/kg 99mTc sulfur colloid. Blood samples were collected for the assessment of plasma urea, creatinine, sodium, and potassium concentrations and arterial gasometry. Samples of liver, spleen, lung and blood clots were obtained and radioactivity was measured. Samples of liver, spleen, lung and kidney were prepared for routine histopathological analysis. Plasma urea, creatinine and potassium concentrations in groups II and III were higher than in group I (P<0.05). Plasma sodium concentrations in groups II and III were lower than in group I (P<0.05). Compensated metabolic acidosis was observed in the presence of postrenal failure. Group II animals showed a lower level of radioactivity in the spleen (0.98) and lung (2.63), and a higher level in the liver (105.51) than control. Group III animals showed a lower level of radioactivity in the spleen (11.94) and a higher level in the liver (61.80), lung (11.30) and blood clot (5.13) than control. In groups II and III liver steatosis and bronchopneumonia were observed. Renal and postrenal failures seem to interfere with blood clearance by the mononuclear phagocytic system.</abstract><cop>Brazil</cop><pub>Associação Brasileira de Divulgação Científica</pub><pmid>11514841</pmid><doi>10.1590/S0100-879X2001000900010</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brazilian journal of medical and biological research, 2001-09, Vol.34 (9), p.1169-1174 |
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| source | SciELO Brazil; IngentaConnect Journals |
| subjects | Acute Kidney Injury - physiopathology Animals BIOLOGY Creatinine - blood Female Liver - cytology Liver - pathology Liver - physiology Lung - cytology Lung - pathology Lung - physiology macrophage Macrophages - physiology Male MEDICINE, RESEARCH & EXPERIMENTAL phagocytosis Phagocytosis - physiology Potassium - blood Rats Rats, Wistar renal failure reticuloendothelial system scintigraphy Sodium - blood Spleen - cytology Spleen - pathology Spleen - physiology Urea - blood |
| title | Influence of acute renal failure on the mononuclear phagocytic system |
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