Isolation of antileishmanial,antimalarial and antimicrobial metabolites from Jatropha multifida

Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections w...

Full description

Saved in:
Bibliographic Details
Published in:Asian Pacific journal of tropical biomedicine 2014-05, Vol.4 (5), p.374-378
Main Authors: Falodun, Abiodun, Imieje, Vincent, Erharuyi, Osayewenre, Joy, Ahomafor, Langer, Peter, Jacob, Melissa, Khan, Shabanna, Abaldry, Mohammed, Hamann, Mark
Format: Article
Language:English
Subjects:
Antimalarial
Antimicrobial
bark
Basic Researches
Cryptococcus neoformans
Jatropha
Jatropha multifida
Leishmaniasis
multifida
Stem
Stem bark
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.Methods:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids（1-3）.Structures were confirmed by comparison of 1D and 2D spectral data with literature.Results:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50of 82 and 8.7 μg/ml,respectively.Conclusions:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections.
ISSN:2221-1691
2588-9222
DOI:10.12980/apjtb.4.2014c1312