An Automated Hardware-in-Loop Testbed for Evaluating Hemorrhagic Shock Resuscitation Controllers

Hemorrhage remains a leading cause of death, with early goal-directed fluid resuscitation being a pillar of mortality prevention. While closed-loop resuscitation can potentially benefit this effort, development of these systems is resource-intensive, making it a challenge to compare infusion control...

Full description

Saved in:
Bibliographic Details
Published in:Bioengineering (Basel) 2022-08, Vol.9 (8), p.373
Main Authors: Snider, Eric J, Berard, David, Vega, Saul J, Hernandez Torres, Sofia I, Avital, Guy, Boice, Emily N
Format: Article
Language:English
Subjects:
Automation
Bioengineering
Blood pressure
Blood products
Clotting
Controllers
Design
flow loop
fluid resuscitation
hardware-in-loop
Hardware-in-the-loop simulation
Hemorrhage
Hemorrhagic shock
infusion
Mass casualty incidents
Medical equipment
Performance evaluation
Performance measurement
Physiological apparatus
Physiology
Pressure transducers
Product development
Properties
Resuscitation
Robust control
Test stands
Troubleshooting
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hemorrhage remains a leading cause of death, with early goal-directed fluid resuscitation being a pillar of mortality prevention. While closed-loop resuscitation can potentially benefit this effort, development of these systems is resource-intensive, making it a challenge to compare infusion controllers and respective hardware within a range of physiologically relevant hemorrhage scenarios. Here, we present a hardware-in-loop automated testbed for resuscitation controllers (HATRC) that provides a simple yet robust methodology to evaluate controllers. HATRC is a flow-loop benchtop system comprised of multiple PhysioVessels which mimic pressure-volume responsiveness for different resuscitation infusates. Subject variability and infusate switching were integrated for more complex testing. Further, HATRC can modulate fluidic resistance to mimic arterial resistance changes after vasopressor administration. Finally, all outflow rates are computer-controlled, with rules to dictate hemorrhage, clotting, and urine rates. Using HATRC, we evaluated a decision-table controller at two sampling rates with different hemorrhage scenarios. HATRC allows quantification of twelve performance metrics for each controller configuration and scenario, producing heterogeneous results and highlighting the need for controller evaluation with multiple hemorrhage scenarios. In conclusion, HATRC can be used to evaluate closed-loop controllers through user-defined hemorrhage scenarios while rating their performance. Extensive controller troubleshooting using HATRC can accelerate product development and subsequent translation.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering9080373