Genetics of oxidative stress in obesity

Obesity is a multifactorial disease characterized by the excessive accumulation of fat in adipose tissue and peripheral organs. Its derived metabolic complications are mediated by the associated oxidative stress, inflammation and hypoxia. Oxidative stress is due to the excessive production of reacti...

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Bibliographic Details
Published in:International Journal of Molecular Sciences 2014-02, Vol.15 (2), p.3118-3144
Main Authors: Rupérez, Azahara I, Gil, Angel, Aguilera, Concepción M
Format: Article
Language:English
Subjects:
antioxidant enzymes
Genetics
Humans
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - pathology
Oxidative Stress
Oxidoreductases - genetics
Oxidoreductases - metabolism
polymorphism
Polymorphism, Single Nucleotide
reactive oxygen species
Reactive Oxygen Species - metabolism
Review
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Obesity is a multifactorial disease characterized by the excessive accumulation of fat in adipose tissue and peripheral organs. Its derived metabolic complications are mediated by the associated oxidative stress, inflammation and hypoxia. Oxidative stress is due to the excessive production of reactive oxygen species or diminished antioxidant defenses. Genetic variants, such as single nucleotide polymorphisms in antioxidant defense system genes, could alter the efficacy of these enzymes and, ultimately, the risk of obesity; thus, studies investigating the role of genetic variations in genes related to oxidative stress could be useful for better understanding the etiology of obesity and its metabolic complications. The lack of existing literature reviews in this field encouraged us to gather the findings from studies focusing on the impact of single nucleotide polymorphisms in antioxidant enzymes, oxidative stress-producing systems and transcription factor genes concerning their association with obesity risk and its phenotypes. In the future, the characterization of these single nucleotide polymorphisms (SNPs) in obese patients could contribute to the development of controlled antioxidant therapies potentially beneficial for the treatment of obesity-derived metabolic complications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms15023118