Loading…
Intensified surveillance after surgery for colorectal cancer significantly improves survival
Postoperative surveillance after curative resection for colorectal cancer has been demonstrated to improve survival. It remains unknown however, whether intensified surveillance provides a significant benefit regarding outcome and survival. This study was aimed at comparing different surveillance st...
Saved in:
| Published in: | European journal of medical research 2010-01, Vol.15 (1), p.25-30, Article 25 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23 |
|---|---|
| cites | cdi_FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23 |
| container_end_page | 30 |
| container_issue | 1 |
| container_start_page | 25 |
| container_title | European journal of medical research |
| container_volume | 15 |
| creator | Laubert, Tilman Bader, F G Oevermann, E Jungbluth, T Unger, L Roblick, U J Bruch, H-P Mirow, L |
| description | Postoperative surveillance after curative resection for colorectal cancer has been demonstrated to improve survival. It remains unknown however, whether intensified surveillance provides a significant benefit regarding outcome and survival. This study was aimed at comparing different surveillance strategies regarding their effect on long-term outcome.
Between 1990 and 2006, all curative resections for colorectal cancer were selected from our prospective colorectal cancer database. All patients were offered to follow our institution's surveillance program according to the ASCO guidelines. We defined surveillance as "intensive" in cases where >70% appointments were attended and the program was completed. As "minimal" we defined surveillance with |
| doi_str_mv | 10.1186/2047-783x-15-1-25 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_2fc7ec03959341deb3878e6a563e1d26</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A280404760</galeid><doaj_id>oai_doaj_org_article_2fc7ec03959341deb3878e6a563e1d26</doaj_id><sourcerecordid>A280404760</sourcerecordid><originalsourceid>FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23</originalsourceid><addsrcrecordid>eNp1kk1r3DAQhk1paZY0P6CXYii0J6f6sGTrUghp0i4Eemmhh4IYy6NdBdnaSt6l--8rZ5OQhVQ6CM2874NGM0XxlpJzSlv5iZG6qZqW_62oqGjFxIti8RD79bJYEFWrinFGT4qzlG5JXpLJRqnXxQkjVCgp20XxezlOOCZnHfZl2sYdOu9hNFiCnTDOoRXGfWlDLE3wIaKZwJdmluSsW43Zmm-T35du2MSww3THcTvwb4pXFnzCs_vztPh5ffXj8lt18_3r8vLipuok41NVC9Mo2VMDlINAkJQQ4Bz6zqDlvFWdaq0lQkIN2DZ1LbjgfQ3KcrDEMH5aLA_cPsCt3kQ3QNzrAE7fBUJcaYiTMx41s6ZBQ7gSite0x463TYsShORIeyYz6_OBtdl2A_YGxymCP4IeZ0a31quw05wL2tZ1Bnw5ADoX_gM4zpgw6Llxem6cpkJTzUTGfLx_Rwx_tpgmPbhkcG4Ohm3SDecNI0KQrHx_UK4gF-hGGzLWzGp9wVpSZ7ScVefPqPLucXAmjGhdjh8ZPjwxrBH8tE7BbycXxnQspAehiSGliPaxVkr0PKrPVvfu6S8_Oh4Gk_8Dmeflkw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733720550</pqid></control><display><type>article</type><title>Intensified surveillance after surgery for colorectal cancer significantly improves survival</title><source>PubMed Central Free</source><creator>Laubert, Tilman ; Bader, F G ; Oevermann, E ; Jungbluth, T ; Unger, L ; Roblick, U J ; Bruch, H-P ; Mirow, L</creator><creatorcontrib>Laubert, Tilman ; Bader, F G ; Oevermann, E ; Jungbluth, T ; Unger, L ; Roblick, U J ; Bruch, H-P ; Mirow, L</creatorcontrib><description><![CDATA[Postoperative surveillance after curative resection for colorectal cancer has been demonstrated to improve survival. It remains unknown however, whether intensified surveillance provides a significant benefit regarding outcome and survival. This study was aimed at comparing different surveillance strategies regarding their effect on long-term outcome.
Between 1990 and 2006, all curative resections for colorectal cancer were selected from our prospective colorectal cancer database. All patients were offered to follow our institution's surveillance program according to the ASCO guidelines. We defined surveillance as "intensive" in cases where >70% appointments were attended and the program was completed. As "minimal" we defined surveillance with <70% of the appointments attended and an incomplete program. As "none" we defined the group which did not take part in any surveillance.
Out of 1469 patients 858 patients underwent "intensive", 297 "minimal" and 314 "none" surveillance. The three groups were well balanced regarding biographical data and tumor characteristics. The 5-year survival rates were 79% (intensive), 76% (minimal) and 54% (none) (OR 1.480, (95% CI 1.135-1.929); p <0.0001), respectively. The 10-year survival rates were 65% (intensive), 50% (minimal) and 31% (none) (p <0.0001), respectively. With a median follow-up of 70 months the median time of survival was 191 months (intensive), 116 months (minimal) and 66 months (none) (p <0.0001). After recurrence, the 5-year survival rates were 32% (intensive, p = 0.034), 13% (minimal, p = 0.001) and 19% (none, p = 0.614). The median time of survival after recurrence was 31 months (intensive, p <0.0001), 21 months (minimal, p <0.0001) and 16 month (none, p <0.0001) respectively.
Intensive surveillance after curative resection of colorectal cancer improves survival. In cases of recurrent disease, intensive surveillance has a positive impact on patients' prognosis. Large randomized, multicenter trials are needed to substantiate these results.]]></description><identifier>ISSN: 0949-2321</identifier><identifier>ISSN: 2047-783X</identifier><identifier>EISSN: 2047-783X</identifier><identifier>DOI: 10.1186/2047-783x-15-1-25</identifier><identifier>PMID: 20159668</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Cancer ; Care and treatment ; colorectal ; Colorectal cancer ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Databases, Factual - standards ; Female ; Germany - epidemiology ; Humans ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Lung Neoplasms - mortality ; Lung Neoplasms - secondary ; Male ; Middle Aged ; Neoplasm Recurrence, Local - mortality ; Neoplasm Staging - mortality ; Patient outcomes ; Population Surveillance ; surveillance ; Survival Analysis</subject><ispartof>European journal of medical research, 2010-01, Vol.15 (1), p.25-30, Article 25</ispartof><rights>COPYRIGHT 2010 BioMed Central Ltd.</rights><rights>Copyright ©2010 I. Holzapfel Publishers 2010 I. Holzapfel Publishers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23</citedby><cites>FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351844/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351844/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20159668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laubert, Tilman</creatorcontrib><creatorcontrib>Bader, F G</creatorcontrib><creatorcontrib>Oevermann, E</creatorcontrib><creatorcontrib>Jungbluth, T</creatorcontrib><creatorcontrib>Unger, L</creatorcontrib><creatorcontrib>Roblick, U J</creatorcontrib><creatorcontrib>Bruch, H-P</creatorcontrib><creatorcontrib>Mirow, L</creatorcontrib><title>Intensified surveillance after surgery for colorectal cancer significantly improves survival</title><title>European journal of medical research</title><addtitle>Eur J Med Res</addtitle><description><![CDATA[Postoperative surveillance after curative resection for colorectal cancer has been demonstrated to improve survival. It remains unknown however, whether intensified surveillance provides a significant benefit regarding outcome and survival. This study was aimed at comparing different surveillance strategies regarding their effect on long-term outcome.
Between 1990 and 2006, all curative resections for colorectal cancer were selected from our prospective colorectal cancer database. All patients were offered to follow our institution's surveillance program according to the ASCO guidelines. We defined surveillance as "intensive" in cases where >70% appointments were attended and the program was completed. As "minimal" we defined surveillance with <70% of the appointments attended and an incomplete program. As "none" we defined the group which did not take part in any surveillance.
Out of 1469 patients 858 patients underwent "intensive", 297 "minimal" and 314 "none" surveillance. The three groups were well balanced regarding biographical data and tumor characteristics. The 5-year survival rates were 79% (intensive), 76% (minimal) and 54% (none) (OR 1.480, (95% CI 1.135-1.929); p <0.0001), respectively. The 10-year survival rates were 65% (intensive), 50% (minimal) and 31% (none) (p <0.0001), respectively. With a median follow-up of 70 months the median time of survival was 191 months (intensive), 116 months (minimal) and 66 months (none) (p <0.0001). After recurrence, the 5-year survival rates were 32% (intensive, p = 0.034), 13% (minimal, p = 0.001) and 19% (none, p = 0.614). The median time of survival after recurrence was 31 months (intensive, p <0.0001), 21 months (minimal, p <0.0001) and 16 month (none, p <0.0001) respectively.
Intensive surveillance after curative resection of colorectal cancer improves survival. In cases of recurrent disease, intensive surveillance has a positive impact on patients' prognosis. Large randomized, multicenter trials are needed to substantiate these results.]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>colorectal</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Databases, Factual - standards</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Staging - mortality</subject><subject>Patient outcomes</subject><subject>Population Surveillance</subject><subject>surveillance</subject><subject>Survival Analysis</subject><issn>0949-2321</issn><issn>2047-783X</issn><issn>2047-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp1kk1r3DAQhk1paZY0P6CXYii0J6f6sGTrUghp0i4Eemmhh4IYy6NdBdnaSt6l--8rZ5OQhVQ6CM2874NGM0XxlpJzSlv5iZG6qZqW_62oqGjFxIti8RD79bJYEFWrinFGT4qzlG5JXpLJRqnXxQkjVCgp20XxezlOOCZnHfZl2sYdOu9hNFiCnTDOoRXGfWlDLE3wIaKZwJdmluSsW43Zmm-T35du2MSww3THcTvwb4pXFnzCs_vztPh5ffXj8lt18_3r8vLipuok41NVC9Mo2VMDlINAkJQQ4Bz6zqDlvFWdaq0lQkIN2DZ1LbjgfQ3KcrDEMH5aLA_cPsCt3kQ3QNzrAE7fBUJcaYiTMx41s6ZBQ7gSite0x463TYsShORIeyYz6_OBtdl2A_YGxymCP4IeZ0a31quw05wL2tZ1Bnw5ADoX_gM4zpgw6Llxem6cpkJTzUTGfLx_Rwx_tpgmPbhkcG4Ohm3SDecNI0KQrHx_UK4gF-hGGzLWzGp9wVpSZ7ScVefPqPLucXAmjGhdjh8ZPjwxrBH8tE7BbycXxnQspAehiSGliPaxVkr0PKrPVvfu6S8_Oh4Gk_8Dmeflkw</recordid><startdate>20100129</startdate><enddate>20100129</enddate><creator>Laubert, Tilman</creator><creator>Bader, F G</creator><creator>Oevermann, E</creator><creator>Jungbluth, T</creator><creator>Unger, L</creator><creator>Roblick, U J</creator><creator>Bruch, H-P</creator><creator>Mirow, L</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20100129</creationdate><title>Intensified surveillance after surgery for colorectal cancer significantly improves survival</title><author>Laubert, Tilman ; Bader, F G ; Oevermann, E ; Jungbluth, T ; Unger, L ; Roblick, U J ; Bruch, H-P ; Mirow, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>colorectal</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Databases, Factual - standards</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Staging - mortality</topic><topic>Patient outcomes</topic><topic>Population Surveillance</topic><topic>surveillance</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laubert, Tilman</creatorcontrib><creatorcontrib>Bader, F G</creatorcontrib><creatorcontrib>Oevermann, E</creatorcontrib><creatorcontrib>Jungbluth, T</creatorcontrib><creatorcontrib>Unger, L</creatorcontrib><creatorcontrib>Roblick, U J</creatorcontrib><creatorcontrib>Bruch, H-P</creatorcontrib><creatorcontrib>Mirow, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>European journal of medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laubert, Tilman</au><au>Bader, F G</au><au>Oevermann, E</au><au>Jungbluth, T</au><au>Unger, L</au><au>Roblick, U J</au><au>Bruch, H-P</au><au>Mirow, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intensified surveillance after surgery for colorectal cancer significantly improves survival</atitle><jtitle>European journal of medical research</jtitle><addtitle>Eur J Med Res</addtitle><date>2010-01-29</date><risdate>2010</risdate><volume>15</volume><issue>1</issue><spage>25</spage><epage>30</epage><pages>25-30</pages><artnum>25</artnum><issn>0949-2321</issn><issn>2047-783X</issn><eissn>2047-783X</eissn><abstract><![CDATA[Postoperative surveillance after curative resection for colorectal cancer has been demonstrated to improve survival. It remains unknown however, whether intensified surveillance provides a significant benefit regarding outcome and survival. This study was aimed at comparing different surveillance strategies regarding their effect on long-term outcome.
Between 1990 and 2006, all curative resections for colorectal cancer were selected from our prospective colorectal cancer database. All patients were offered to follow our institution's surveillance program according to the ASCO guidelines. We defined surveillance as "intensive" in cases where >70% appointments were attended and the program was completed. As "minimal" we defined surveillance with <70% of the appointments attended and an incomplete program. As "none" we defined the group which did not take part in any surveillance.
Out of 1469 patients 858 patients underwent "intensive", 297 "minimal" and 314 "none" surveillance. The three groups were well balanced regarding biographical data and tumor characteristics. The 5-year survival rates were 79% (intensive), 76% (minimal) and 54% (none) (OR 1.480, (95% CI 1.135-1.929); p <0.0001), respectively. The 10-year survival rates were 65% (intensive), 50% (minimal) and 31% (none) (p <0.0001), respectively. With a median follow-up of 70 months the median time of survival was 191 months (intensive), 116 months (minimal) and 66 months (none) (p <0.0001). After recurrence, the 5-year survival rates were 32% (intensive, p = 0.034), 13% (minimal, p = 0.001) and 19% (none, p = 0.614). The median time of survival after recurrence was 31 months (intensive, p <0.0001), 21 months (minimal, p <0.0001) and 16 month (none, p <0.0001) respectively.
Intensive surveillance after curative resection of colorectal cancer improves survival. In cases of recurrent disease, intensive surveillance has a positive impact on patients' prognosis. Large randomized, multicenter trials are needed to substantiate these results.]]></abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>20159668</pmid><doi>10.1186/2047-783x-15-1-25</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0949-2321 |
| ispartof | European journal of medical research, 2010-01, Vol.15 (1), p.25-30, Article 25 |
| issn | 0949-2321 2047-783X 2047-783X |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_2fc7ec03959341deb3878e6a563e1d26 |
| source | PubMed Central Free |
| subjects | Aged Aged, 80 and over Cancer Care and treatment colorectal Colorectal cancer Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Databases, Factual - standards Female Germany - epidemiology Humans Liver Neoplasms - mortality Liver Neoplasms - secondary Lung Neoplasms - mortality Lung Neoplasms - secondary Male Middle Aged Neoplasm Recurrence, Local - mortality Neoplasm Staging - mortality Patient outcomes Population Surveillance surveillance Survival Analysis |
| title | Intensified surveillance after surgery for colorectal cancer significantly improves survival |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T15%3A53%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intensified%20surveillance%20after%20surgery%20for%20colorectal%20cancer%20significantly%20improves%20survival&rft.jtitle=European%20journal%20of%20medical%20research&rft.au=Laubert,%20Tilman&rft.date=2010-01-29&rft.volume=15&rft.issue=1&rft.spage=25&rft.epage=30&rft.pages=25-30&rft.artnum=25&rft.issn=0949-2321&rft.eissn=2047-783X&rft_id=info:doi/10.1186/2047-783x-15-1-25&rft_dat=%3Cgale_doaj_%3EA280404760%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b623t-45c796d1ca13a5ea6100a33adbcef3389b98ff056a4ae87445353d4a9f3af0c23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=733720550&rft_id=info:pmid/20159668&rft_galeid=A280404760&rfr_iscdi=true |