Magnesium and osteoporosis: current state of knowledge and future research directions

A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone...

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Bibliographic Details
Published in:Nutrients 2013-07, Vol.5 (8), p.3022-3033
Main Authors: Castiglioni, Sara, Cazzaniga, Alessandra, Albisetti, Walter, Maier, Jeanette A M
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - drug effects
Bone and Bones - metabolism
Dietary Supplements
Disease Models, Animal
Homeostasis
Humans
magnesium
Magnesium - administration & dosage
Magnesium Deficiency - complications
Magnesium Deficiency - drug therapy
osteoblast
osteoclast
osteoporosis
Osteoporosis - complications
Osteoporosis - drug therapy
Osteoporosis - prevention & control
Parathyroid Hormone - metabolism
Review
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Summary:A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu5083022